SH2B3 Antikörper (AA 161-260) (Biotin)

Produktnummer ABIN1700355

Produktdetails anti-SH2B3 Antikörper (Biotin)

Target: SH2B3 (SH2B Adaptor Protein 3 (SH2B3))

Bindungsspezifität: AA 161-260

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SH2B3 Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Homologie: Human,Mouse,Rat,Dog,Cow,Sheep,Horse,Monkey

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human LNK

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu SH2B3

Target: SH2B3 (SH2B Adaptor Protein 3 (SH2B3))

Andere Bezeichnung: LNK (SH2B3 Produkte)

Synonyme: LNK antikoerper, IDDM20 antikoerper, AI429800 antikoerper, Lnk antikoerper, SH2B adaptor protein 3 antikoerper, SH2B3 antikoerper, Sh2b3 antikoerper

Hintergrund:

Synonyms: IDDM20,Lymphocyte adapter protein,Lymphocyte specic adapter protein,Lymphocyte specic adapter protein Lnk,Lymphocyte-specic adapter protein Lnk,SH2B adapter protein 3,SH2B adaptor protein 3,Sh2b3,SH2B3_HUMAN,Signal transduction protein Lnk.

Background: APS (adapter molecule containing PH and SH2 domains), SH2-B and Lnk compose a family of adapter proteins, which contain a pleckstrin homology (PH) domain, an SH2 domain and a tyrosine phosphorylation site. Stimulation of B cell receptor (BCR) or T cell receptor (TCR) results in the phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of BCR, TCR and several substrates. APS, SH2-B and Lnk may bind to the ITAM domain of BCR and TCR. Lnk is tyrosine phosphorylated in response to TCR stimulation and APS has been shown to be tyrosine phosphorylated in response to BCR stimulation.