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FANCA Antikörper (AA 461-560) (Biotin)

FANCA Reaktivität: Ratte ELISA, IHC (p), IHC (fro) Wirt: Kaninchen Polyclonal Biotin
Produktnummer ABIN1700471
  • Target Alle FANCA Antikörper anzeigen
    FANCA (Fanconi Anemia Group A Protein (FANCA))
    Bindungsspezifität
    • 14
    • 13
    • 7
    • 7
    • 6
    • 6
    • 6
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 461-560
    Reaktivität
    • 61
    • 18
    • 11
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Ratte
    Wirt
    • 72
    • 3
    Kaninchen
    Klonalität
    • 73
    • 2
    Polyklonal
    Konjugat
    • 34
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser FANCA Antikörper ist konjugiert mit Biotin
    Applikation
    • 38
    • 28
    • 13
    • 13
    • 12
    • 9
    • 9
    • 7
    • 5
    • 2
    • 1
    • 1
    • 1
    ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Kreuzreaktivität
    Ratte
    Homologie
    Human,Mouse,Chicken,Rabbit
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human FANCA
    Isotyp
    IgG
    Top Product
    Discover our top product FANCA Primärantikörper
  • Applikationshinweise
    IHC-P 1:200-400
    IHC-F 1:100-500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C for 12 months.
    Haltbarkeit
    12 months
  • Target
    FANCA (Fanconi Anemia Group A Protein (FANCA))
    Andere Bezeichnung
    FANCA (FANCA Produkte)
    Synonyme
    FA antikoerper, FA-H antikoerper, FA1 antikoerper, FAA antikoerper, FACA antikoerper, FAH antikoerper, FANCH antikoerper, AW208693 antikoerper, Fanconi anemia complementation group A antikoerper, Fanconi anemia, complementation group A antikoerper, FANCA antikoerper, Fanca antikoerper
    Hintergrund

    Synonyms: FA 1, FA, FA H, FA1, FAA, FACA, FAH, Fanca, FANCA_HUMAN, FANCH, Fanconi anemia complementation group A, Fanconi anemia complementation group H, Fanconi anemia group A protein, Fanconi anemia type 1, MGC75158, Protein FACA.

    Background: Fanconi anemia (FA) is an autosomal recessive disorder characterized by bone marrow failure, birth defects and chromosomal instability. At the cellular level, FA is characterized by spontaneous chromosomal breakage and a unique hypersensitivity to DNA cross-linking agents. At least eight complementation groups (A-G) have been identified and six FA genes (for subtypes A, C, D2, E, F and G) have been cloned. The FA proteins lack sequence homologies or motifs that could point to a molecular function. The cellular accumulation of FA proteins, including FANCA and FANCG, is subject to regulation by TNF alpha signaling. Phosphorylation of FANC (Fanconi anemia complementation group) proteins is thought to be important for the function of the FA pathway. FANCA, also known as FACA and FANCH, associates with the Brm-related gene 1 (BRG1) product, a subunit of the SWI/SNF complex which remodels chromatin structure through a DNA-dependent ATPase activity. FANCA is mainly expressed in lymphoid tissues, testis and ovary. The amino-terminal region of the FANCA protein is required for FANCG binding, FANCC binding, nuclear localization and functional activity of the complex. The human FANCA gene maps to chromosome 16q24.3 and encodes a 1,455 amino acid protein.

    Gen-ID
    2175
    Pathways
    DNA Reparatur
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