GEMIN7 Antikörper (AA 21-120) (Biotin)

Produktnummer ABIN1700552

Produktdetails anti-GEMIN7 Antikörper (Biotin)

Target: GEMIN7 (Gem (Nuclear Organelle) Associated Protein 7 (GEMIN7))

Bindungsspezifität: AA 21-120

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GEMIN7 Antikörper ist konjugiert mit Biotin

Applikation: ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität: Human, Ratte

Homologie: Mouse,Dog,Cow,Horse,Chicken

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Gemin 7

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu GEMIN7

Target: GEMIN7 (Gem (Nuclear Organelle) Associated Protein 7 (GEMIN7))

Andere Bezeichnung: Gemin 7 (GEMIN7 Produkte)

Synonyme: SIP3 antikoerper, GEMIN7 antikoerper, Gemin7 antikoerper, 2400008I04Rik antikoerper, AI120175 antikoerper, AI461688 antikoerper, gem nuclear organelle associated protein 7 antikoerper, gem (nuclear organelle) associated protein 7 antikoerper, GEMIN7 antikoerper, Gemin7 antikoerper

Hintergrund:

Synonyms: SIP3, Gemin7, Gemin-7, GEMI7_HUMAN.

Background: Gemin7 is a 131 amino acid protein encoded by the mouse gene Gemin7. Gemin7, along with Gemin6, is a significant component of the the large multiprotein human SMN complex. The SMN complex functions as an assembly machine for small nuclear ribonucleoproteins (snRNPs)-the major components of the spliceosome. The survival of motor neurons (SMN) protein, a product of the disease gene of the common neurodegenerative disease, spinal muscular atrophy, is also part of the SMN complex. Although Gemin6 and Gemin7 have no significant sequence similarity with Sm proteins, both adopt canonical Sm folds. Moreover, Gemin6 and Gemin7 exist as a heterodimer, and interact with each other via an interface similar to that which mediates interactions among the Sm proteins. The Gemin6/Gemin7 complex binds to Sm proteins and might help organize Sm proteins for formation of Sm rings on snRNA targets.

Gen-ID: 79760

Pathways: Ribonucleoprotein Complex Subunit Organization