MIB1 Antikörper (AA 101-200) (Biotin)
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- Target Alle MIB1 Antikörper anzeigen
- MIB1 (Mindbomb E3 Ubiquitin Protein Ligase 1 (MIB1))
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Bindungsspezifität
- AA 101-200
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser MIB1 Antikörper ist konjugiert mit Biotin
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Applikation
- ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Homologie
- Human,Mouse,Rat,Dog,Cow,Chicken,Rabbit
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human Mib1/Mindbomb
- Isotyp
- IgG
- Top Product
- Discover our top product MIB1 Primärantikörper
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- Applikationshinweise
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IHC-P 1:200-400
IHC-F 1:100-500 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C for 12 months.
- Haltbarkeit
- 12 months
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- Target
- MIB1 (Mindbomb E3 Ubiquitin Protein Ligase 1 (MIB1))
- Abstract
- MIB1 Produkte
- Synonyme
- DIP-1 antikoerper, DIP1 antikoerper, LVNC7 antikoerper, MIB antikoerper, ZZANK2 antikoerper, ZZZ6 antikoerper, E430019M12Rik antikoerper, Mib antikoerper, mKIAA1323 antikoerper, dip-1 antikoerper, mib antikoerper, mindbomb antikoerper, cg5841 antikoerper, chunp6889 antikoerper, fe47f05 antikoerper, im:7148100 antikoerper, mib1 antikoerper, wu:fe47f05 antikoerper, CG5841 antikoerper, D-mib antikoerper, D-mib1 antikoerper, Dmel\CG5841 antikoerper, Dmib antikoerper, MIB1 antikoerper, Mib1 antikoerper, dmib1 antikoerper, l(3)72CDa antikoerper, l(3)72Db antikoerper, mib1/2 antikoerper, mind-bomb antikoerper, mindbomb E3 ubiquitin protein ligase 1 antikoerper, mindbomb E3 ubiquitin protein ligase 1 L homeolog antikoerper, mind bomb 1 antikoerper, MIB1 antikoerper, Mib1 antikoerper, mib1.L antikoerper, mib1 antikoerper
- Hintergrund
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Synonyms: DAPK-interacting protein 1, Dip 1, DIP-1, Dip1, E3 ubiquitin protein ligase MIB 1, E3 ubiquitin protein ligase MIB1, E3 ubiquitin-protein ligase mib1, mib1, MIB1_HUMAN, Mind bomb homolog 1, Zinc finger ZZ type with ankyrin repeat domain protein 2.
Background: MIB1 is a 1006 amino acid E3 ubiquitin ligase that activates the Notch ligand, Delta. MIB1 ubiquinates Delta by binding to its intracellular domain, leading to the endocytosis and eventual degradation of the Delta receptor, which, paradoxically, results in the up-regulation of receptor activity and enhances Notch signaling. MIB1 also interacts with DAPK, a protein that plays an important role in the regulation of apoptosis. Ubiquination of DAPK leads to inhibition of caspase-dependent apoptosis, therefore it is likely that overexpression of MIB1 can lead to tumor growth. Although it seems to be widely expressed at low levels, MIB1 is expressed at highest concentrations in the CNS and ovary. Both DAPK and MIB1 are overexpressed in epileptic brain tissue, suggesting that they probably cooperate as regulators of neuronal death in epilepsy.
- Gen-ID
- 57534
- Pathways
- SARS-CoV-2 Protein Interaktom, Phosphorylierungen bei SARS-CoV-2 Infektion
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