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ASAH1 Antikörper (AA 301-395) (Biotin)

ASAH1 Reaktivität: Maus WB, ELISA, IHC (p), IHC (fro) Wirt: Kaninchen Polyclonal Biotin
Produktnummer ABIN1700602
  • Target Alle ASAH1 Antikörper anzeigen
    ASAH1 (N-Acylsphingosine Amidohydrolase (Acid Ceramidase) 1 (ASAH1))
    Bindungsspezifität
    • 14
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 301-395
    Reaktivität
    • 30
    • 21
    • 6
    • 4
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Maus
    Wirt
    • 39
    • 5
    Kaninchen
    Klonalität
    • 39
    • 5
    Polyklonal
    Konjugat
    • 21
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser ASAH1 Antikörper ist konjugiert mit Biotin
    Applikation
    • 33
    • 13
    • 13
    • 13
    • 10
    • 9
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Kreuzreaktivität
    Maus
    Homologie
    Human,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Acid ceramidase subunit beta
    Isotyp
    IgG
    Top Product
    Discover our top product ASAH1 Primärantikörper
  • Applikationshinweise
    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C for 12 months.
    Haltbarkeit
    12 months
  • Target
    ASAH1 (N-Acylsphingosine Amidohydrolase (Acid Ceramidase) 1 (ASAH1))
    Andere Bezeichnung
    ASAH1 (ASAH1 Produkte)
    Synonyme
    AC antikoerper, ACDase antikoerper, ASAH antikoerper, PHP antikoerper, PHP32 antikoerper, SMAPME antikoerper, 2310081N20Rik antikoerper, Asah antikoerper, MGC82286 antikoerper, asah1 antikoerper, zgc:101637 antikoerper, ASAH1 antikoerper, zgc:66026 antikoerper, N-acylsphingosine amidohydrolase 1 antikoerper, N-acylsphingosine amidohydrolase (acid ceramidase) 1 antikoerper, N-acylsphingosine amidohydrolase (acid ceramidase) 1 L homeolog antikoerper, N-acylsphingosine amidohydrolase (acid ceramidase) 1a antikoerper, Acid ceramidase antikoerper, N-acylsphingosine amidohydrolase (acid ceramidase) 1b antikoerper, ASAH1 antikoerper, Asah1 antikoerper, asah1.L antikoerper, asah1a antikoerper, asah-1 antikoerper, asah1b antikoerper
    Hintergrund

    Synonyms: AC, ACDase, Acid CDase, Acid ceramidase, Acid ceramidase precursor, Acid ceramidase subunit beta, Acylsphingosine deacylase, ASAH 1, ASAH, ASAH1, ASAH1_HUMAN, FLJ21558, FLJ22079, N acylsphingosine amidohydrolase acid ceramidase 1, N acylsphingosine amidohydrolase 1, N acylsphingosine amidohydrolase, N-acylsphingosine amidohydrolase, PHP, PHP32, Putative 32 kDa heart protein.

    Background: Acid ceramidase catalyzes the degradation of ceramide in normal tissues, and deficiency leads to accumulation of ceramide in tissues, a hallmark of Farber disease. Effected individuals experience early onset joint problems and neurological problems, owing to mutations in the acid ceramidase gene. Bioinformatic analysis of gene expression also reveals acid ceramidase to be among the 5 most important genes associated with melanoma. In addition to ceramide hydrolysis, purified acid ceramidase also exhibits the ability to catalyze ceramide synthesis, utilizing [14C]lauric acid and sphingosine as substrates. Interestingly, pH regulates which reaction is favored, for hydrolysis the pH optimum is 4.5, whereas for the reverse reaction favors a pH of 5.5, further supporting a complex and central role for acid ceramidase in sphingolipid metabolism.

    Gen-ID
    427
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