GLDC Antikörper (AA 51-150) (Biotin)

Produktnummer ABIN1700958

Produktdetails anti-GLDC Antikörper (Biotin)

Target: GLDC (Glycine Dehydrogenase (GLDC))

Bindungsspezifität: AA 51-150

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GLDC Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Homologie: Human,Mouse,Rat,Dog,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GLDC

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu GLDC

Target: GLDC (Glycine Dehydrogenase (GLDC))

Andere Bezeichnung: GLDC (GLDC Produkte)

Synonyme: PSPTO1276 antikoerper, Tb07.43M14.350 antikoerper, DDBDRAFT_0219205 antikoerper, DDBDRAFT_0231130 antikoerper, DDB_0219205 antikoerper, DDB_0231130 antikoerper, D030049L12Rik antikoerper, D19Wsu57e antikoerper, GCE antikoerper, GCSP antikoerper, HYGN1 antikoerper, fb23b05 antikoerper, wu:fb23b05 antikoerper, zgc:66198 antikoerper, gldc antikoerper, glycine dehydrogenase (decarboxylating) GcvP antikoerper, glycine dehydrogenase antikoerper, glycine cleavage system P-protein antikoerper, glycine decarboxylase antikoerper, glycine dehydrogenase (decarboxylating) antikoerper, glycine decarboxylase S homeolog antikoerper, gcvP antikoerper, Tb927.7.1910 antikoerper, Gldc antikoerper, GLDC antikoerper, gldc antikoerper, gldc.S antikoerper

Hintergrund:

Synonyms: GCE, GCSP, GCSP_HUMAN, GLDC, Glycine cleavage system P protein, glycine cleavage system protein P, Glycine decarboxylase, glycine decarboxylase P protein, Glycine dehydrogenase decarboxylating mitochondrial, Glycine dehydrogenase [decarboxylating], mitochondrial, Gycine dehydrogenase decarboxylating, HYGN1, MGC138198, MGC138200, NKH.

Background: The glycine cleavage system is comprised of AMT (known as Protein T), GCSH (known as Protein H), DLD (known as Protein L) and GLDC (known as Protein P), all of which work together to catalyze the cleavage and degradation of glycine. GLDC (glycine dehydrogenase ), also known as GCE, GCSP (glycine cleavage system P protein) or HYGN1, is a 1,020 amino acid protein that localizes to the mitochondria and belongs to the gcvP family. GLDC binds to glycine and enables the methylamine group from glycine to be transferred to the Protein T. GLDC exists as a homodimer and utilizes pyridoxal phosphate as a cofactor. Mutations in the gene encoding GLDC leads to nonketotic hyperglycinemia (NKH), also known as glycine encephalopathy (GCE), an autosomal recessive disease characterized by accumulation of a large amount of glycine in body fluid and by severe neurological symptoms.

Gen-ID: 2731