TLE4 Antikörper (AA 681-773) (Biotin)

Produktnummer ABIN1701385

Produktdetails anti-TLE4 Antikörper (Biotin)

Target: TLE4 (Transducin-like Enhancer Protein 4 (TLE4))

Bindungsspezifität: AA 681-773

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TLE4 Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Homologie: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human TLE4

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu TLE4

Target: TLE4 (Transducin-like Enhancer Protein 4 (TLE4))

Andere Bezeichnung: TLE4 (TLE4 Produkte)

Synonyme: TLE4 antikoerper, NV17443 antikoerper, BCE-1 antikoerper, BCE1 antikoerper, E(spI) antikoerper, ESG antikoerper, ESG4 antikoerper, GRG4 antikoerper, Esp2 antikoerper, Grg4 antikoerper, XGrg-4 antikoerper, XTCF-4 antikoerper, Xgrg4 antikoerper, Xtle4 antikoerper, esg4 antikoerper, grg4 antikoerper, gro antikoerper, 5730411M05Rik antikoerper, AA792082 antikoerper, Bce-1 antikoerper, Bce1 antikoerper, ESTM13 antikoerper, ESTM14 antikoerper, X83332 antikoerper, X83333 antikoerper, transducin like enhancer of split 4 antikoerper, transducin-like enhancer protein 4 antikoerper, protein groucho-1 antikoerper, transducin-like enhancer of split 4 antikoerper, transducin like enhancer of split 4-Z 1 antikoerper, transducin like enhancer of split 4 S homeolog antikoerper, TLE4 antikoerper, LOC706619 antikoerper, LOC100117159 antikoerper, LOC100462498 antikoerper, Tle4 antikoerper, TLE4Z1 antikoerper, LOC476317 antikoerper, tle4.S antikoerper

Hintergrund:

Synonyms: B lymphocyte gene 1, B lymphocyte gene 1, enhancer of split groucho 4, enhancer of split groucho 4, ESG4, ESG4, KIAA1261, TIM, TIM1, timeless Drosophila homolog, TLE4, transducin-like enhancer of split 4, transducin-like enhancer of split 4, TLE4_HUMAN.

Background: The Notch signaling pathway controls cellular interactions important for the specification of a variety of fates in both invertebrates and vertebrates. Key players in the Notch pathway are the TLE genes (for transducin-like enhancer of split, also designated ESG for enhancer of split groucho), which are human homologs of the Drosophila groucho gene. Groucho is a transcriptional repressor that plays a key role in neurogenesis, segmentation and sex determination. TLEs associate with chromatin in live cells and specifically with Histone H3, but not with other core histones. Expression of the TLE genes, TLE1, TLE2, TLE3 and TLE4, correlate with immature epithelial cells that are progressing toward a terminally differentiated state, suggesting a role during epithelial differentiation. TLE1, TLE2 and TLE3 have elevated expression in cervical squamous metaplasias and carcinomas, while TLE4 is most highly expressed in the brain, particularly in the caudate nucleus. TLE1 and TLE4 contain SP and WD40 domains, through which TLE1 binds AML1 to inhibit AML1-induced transactivation of the CSF1 receptor. In early stages of cell differentiation, TLE1 is upregulated, and TLE2 and TLE4 are downregulated. In later stages, TLE2 and TLE4 are upregulated, and expression of TLE1 decreases.

Gen-ID: 7091

Pathways: WNT Signalweg