GORASP2 Antikörper (AA 151-250) (Biotin)

Produktnummer ABIN1701529

Produktdetails anti-GORASP2 Antikörper (Biotin)

Target: GORASP2 (Golgi Reassembly Stacking Protein 2, 55kDa (GORASP2))

Bindungsspezifität: AA 151-250

Reaktivität: Maus, Xenopus laevis

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GORASP2 Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Maus, Xenopus laevis

Homologie: Human,Rat,Cow,Sheep,Pig,Horse,Rabbit,Zebrafish

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Golgi phosphoprotein 6

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu GORASP2

Target: GORASP2 (Golgi Reassembly Stacking Protein 2, 55kDa (GORASP2))

Andere Bezeichnung: Golgi phosphoprotein 6 (GORASP2 Produkte)

Synonyme: MGC53281 antikoerper, MGC132131 antikoerper, MGC73072 antikoerper, zgc:73072 antikoerper, DKFZp459O1715 antikoerper, 0610011A07Rik antikoerper, 2410043M02Rik antikoerper, 5730520M13Rik antikoerper, 9430094F20Rik antikoerper, AW552058 antikoerper, GOLPH2 antikoerper, GRASP55 antikoerper, GRS2 antikoerper, p59 antikoerper, Grs2 antikoerper, GOLPH6 antikoerper, golgi reassembly stacking protein 2 L homeolog antikoerper, golgi reassembly stacking protein 2 antikoerper, gorasp2.L antikoerper, gorasp2 antikoerper, GORASP2 antikoerper, CC1G_02936 antikoerper, Gorasp2 antikoerper

Hintergrund:

Synonyms: Golgi phosphoprotein 6, Golgi reassembly stacking protein 2, Golgi reassembly stacking protein 2, 55 kDa, Golgi reassembly stacking protein of 55 kDa, Golgi reassembly-stacking protein 2, Golgi reassembly-stacking protein of 55 kDa, GOLPH2, GOLPH6, GORASP2, GORS2_HUMAN, GRASP55, GRS2, p59, RP23-428O15.1.

Background: The Golgi apparatus is a highly complex organelle comprised of a stack of cisternal membranes on the secretory pathway from the ER to the cell surface. The structure is maintained by an exoskeleton or Golgi matrix constructed from a family of coiled-coil protein, the golgins and other peripheral membrane components such as GRASP55 and GRASP65 (1). GRASP55 (Golgi reassembly stacking protien or p59) is a component of the Golgi stacking machinery. GRASP55 is highly homologous to GRASP65 and contains two PDZ domains. GRASP55 is myristoylated and palmitoylated. Unlike GRASP65, GRASP55 does not have detectable binding with the vesicle docking protein GM130 and is located on the medial-Golgi rather than cis-Golgi. Both GRASP55 and GRASP65 function in the stacking of Golgi Cisternae (2,3). The novel coiled-coil protein golgin 45 interacts with GRASP55 and the GTP form of Rab 2, suggesting that GRASP55 and golgin 45 form a Rab 2 effector complex on medial-Golgi essential for normal protein transport and Golgi structure (4). ERK2 directly phosphorylates GRASP55, which is phosphorylated in mitotic cells, suggesting that mitogen-activated protein kinase kinase (MKK)/ERK pathway phosphorylates the Golgi during mitosis (5).

Gen-ID: 26003