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BORA Antikörper (AA 31-130) (Cy7)

BORA Reaktivität: Human WB, IF (cc), IF (p) Wirt: Kaninchen Polyclonal Cy7
Produktnummer ABIN1708559
  • Target Alle BORA Antikörper anzeigen
    BORA (Protein Aurora Borealis (BORA))
    Bindungsspezifität
    • 14
    • 7
    • 6
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 31-130
    Reaktivität
    • 44
    • 13
    • 13
    Human
    Wirt
    • 41
    • 2
    • 1
    Kaninchen
    Klonalität
    • 44
    Polyklonal
    Konjugat
    • 13
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser BORA Antikörper ist konjugiert mit Cy7
    Applikation
    • 23
    • 12
    • 12
    • 12
    • 7
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Homologie
    Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human BORA
    Isotyp
    IgG
    Top Product
    Discover our top product BORA Primärantikörper
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    BORA (Protein Aurora Borealis (BORA))
    Andere Bezeichnung
    BORA (BORA Produkte)
    Synonyme
    CG6897 antikoerper, Dmel\\CG6897 antikoerper, zgc:101616 antikoerper, C13orf34 antikoerper, 6720463M24Rik antikoerper, AI317232 antikoerper, RGD1309522 antikoerper, c13orf34 antikoerper, C12H13orf34 antikoerper, aurora borealis antikoerper, bora, aurora kinase A activator antikoerper, protein aurora borealis antikoerper, bora, aurora kinase A activator S homeolog antikoerper, bora antikoerper, Tsp_06066 antikoerper, Bora antikoerper, BORA antikoerper, bora.S antikoerper
    Hintergrund

    Synonyms: Aurora borealis, bora, BORA_HUMAN, C13orf34, Chromosome 13 open reading frame 34, FLJ22624, HsBora, Protein aurora borealis, RP11-342J4.2.

    Background: Aurora related kinase-1 (ARK-1) is a centrosome-associated serine/threonine kinase that regulates centrosome separation, bipolar spindle assembly and chromosome segregation during mitosis. Bora (protein aurora borealis) is a 559 amino acid protein that activates ARK-1. Bora is localized to the nucleus until mitosis is initiated, when it then translocates to the cytoplasm. This translocation is dependent on activated Cdc2, which releases Bora to bind and activate ARK-1 in the cytoplasm. Plk (polo-like kinase) interacts with Bora to control the accessibility of its activation loop for phosphorylation and activation on its N-terminus by ARK-1. It is through this mechanism that Bora and ARK-1 control cellular mitotic entry. Downregulation of the gene encoding Bora results in multipolar spindles in mitosis, a phenomenon that is also observed when ARK-1 function is blocked.

    Gen-ID
    79866
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