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WDFY1 Antikörper (AA 21-120) (Cy7)

WDFY1 Reaktivität: Ratte FACS, IF (p), IF (cc) Wirt: Kaninchen Polyclonal Cy7
Produktnummer ABIN1708646
  • Target Alle WDFY1 Antikörper anzeigen
    WDFY1 (WD Repeat and FYVE Domain Containing 1 (WDFY1))
    Bindungsspezifität
    • 15
    • 6
    • 4
    • 1
    • 1
    AA 21-120
    Reaktivität
    • 19
    • 18
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    Ratte
    Wirt
    • 32
    • 1
    Kaninchen
    Klonalität
    • 33
    Polyklonal
    Konjugat
    • 9
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser WDFY1 Antikörper ist konjugiert mit Cy7
    Applikation
    • 13
    • 12
    • 12
    • 9
    • 7
    • 5
    • 3
    • 2
    • 1
    Flow Cytometry (FACS), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))
    Kreuzreaktivität
    Ratte
    Homologie
    Human,Mouse,Dog,Cow,Pig,Horse,Rabbit
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human WDFY1
    Isotyp
    IgG
    Top Product
    Discover our top product WDFY1 Primärantikörper
  • Applikationshinweise
    FCM 1:20-100
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    WDFY1 (WD Repeat and FYVE Domain Containing 1 (WDFY1))
    Andere Bezeichnung
    WDFY1 + WDFY2 (WDFY1 Produkte)
    Synonyme
    FENS-1 antikoerper, WDF1 antikoerper, ZFYVE17 antikoerper, 1700013B03Rik antikoerper, 1700120F24Rik antikoerper, Jr1 antikoerper, mKIAA1435 antikoerper, MGC93914 antikoerper, zgc:101764 antikoerper, zgc:109909 antikoerper, WD repeat and FYVE domain containing 1 antikoerper, WDFY1 antikoerper, Wdfy1 antikoerper, wdfy1 antikoerper
    Hintergrund

    Synonyms: FENS 1, FENS-1, FENS1, KIAA1435, Phosphoinositide binding protein 1, Phosphoinositide binding protein SR1, Phosphoinositide-binding protein 1, WD repeat and FYVE domain containing 1, WD repeat and FYVE domain-containing protein 1, WD40 and FYVE domain containing protein 1, WD40- and FYVE domain-containing protein 1, WDF1, WDFY1, WDFY1_HUMAN, ZFYVE17, Zinc finger FYVE domain containing protein 17, Zinc finger FYVE domain-containing protein 17, WDFY2, WD repeat and FYVE domain-containing protein 2, Propeller-FYVE protein, WD40- and FYVE domain-containing protein 2, Zinc finger FYVE domain-containing protein 22, WDF2, ZFYVE22

    Background: WD-repeats are motifs that are found in a variety of proteins and are characterized by a conserved core of 40-60 amino acids that commonly form a tertiary propeller structure. While proteins that contain WD-repeats participate in a wide range of cellular functions, they are generally involved in regulatory mechanisms concerning chromatin assembly, cell cycle control, signal transduction, RNA processing, apoptosis and vesicular trafficking. WDFY1 positively regulates TLR3- and TLR4-mediated signaling pathways by bridging the interaction between TLR3 or TLR4 and TICAM1. WDFY1 Promotes TLR3/4 ligand-induced activation of transcription factors IRF3 and NF-kappa-B, as well as the production of IFN-beta and inflammatory cytokines. WDFY2 acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2. WDFY2 positively regulates adipocyte differentiation, by facilitating the phosphorylation and thus inactivation of the anti-adipogenetic transcription factor FOXO1 by the kinase AKT1

    Gen-ID
    57590, 115825
    UniProt
    Q8IWB7, Q96P53
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