WDFY1 Antikörper (AA 21-120) (FITC)
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- Target Alle WDFY1 Antikörper anzeigen
- WDFY1 (WD Repeat and FYVE Domain Containing 1 (WDFY1))
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Bindungsspezifität
- AA 21-120
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Reaktivität
- Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser WDFY1 Antikörper ist konjugiert mit FITC
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Applikation
- Flow Cytometry (FACS), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))
- Kreuzreaktivität
- Ratte
- Homologie
- Human,Mouse,Dog,Cow,Pig,Horse,Rabbit
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human WDFY1
- Isotyp
- IgG
- Top Product
- Discover our top product WDFY1 Primärantikörper
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- Applikationshinweise
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FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- WDFY1 (WD Repeat and FYVE Domain Containing 1 (WDFY1))
- Andere Bezeichnung
- WDFY1 + WDFY2 (WDFY1 Produkte)
- Synonyme
- FENS-1 antikoerper, WDF1 antikoerper, ZFYVE17 antikoerper, 1700013B03Rik antikoerper, 1700120F24Rik antikoerper, Jr1 antikoerper, mKIAA1435 antikoerper, MGC93914 antikoerper, zgc:101764 antikoerper, zgc:109909 antikoerper, WD repeat and FYVE domain containing 1 antikoerper, WDFY1 antikoerper, Wdfy1 antikoerper, wdfy1 antikoerper
- Hintergrund
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Synonyms: FENS 1, FENS-1, FENS1, KIAA1435, Phosphoinositide binding protein 1, Phosphoinositide binding protein SR1, Phosphoinositide-binding protein 1, WD repeat and FYVE domain containing 1, WD repeat and FYVE domain-containing protein 1, WD40 and FYVE domain containing protein 1, WD40- and FYVE domain-containing protein 1, WDF1, WDFY1, WDFY1_HUMAN, ZFYVE17, Zinc finger FYVE domain containing protein 17, Zinc finger FYVE domain-containing protein 17, WDFY2, WD repeat and FYVE domain-containing protein 2, Propeller-FYVE protein, WD40- and FYVE domain-containing protein 2, Zinc finger FYVE domain-containing protein 22, WDF2, ZFYVE22
Background: WD-repeats are motifs that are found in a variety of proteins and are characterized by a conserved core of 40-60 amino acids that commonly form a tertiary propeller structure. While proteins that contain WD-repeats participate in a wide range of cellular functions, they are generally involved in regulatory mechanisms concerning chromatin assembly, cell cycle control, signal transduction, RNA processing, apoptosis and vesicular trafficking. WDFY1 positively regulates TLR3- and TLR4-mediated signaling pathways by bridging the interaction between TLR3 or TLR4 and TICAM1. WDFY1 Promotes TLR3/4 ligand-induced activation of transcription factors IRF3 and NF-kappa-B, as well as the production of IFN-beta and inflammatory cytokines. WDFY2 acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2. WDFY2 positively regulates adipocyte differentiation, by facilitating the phosphorylation and thus inactivation of the anti-adipogenetic transcription factor FOXO1 by the kinase AKT1
- Gen-ID
- 57590, 115825
- UniProt
- Q8IWB7, Q96P53
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