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FANCM Antikörper (AA 831-930) (HRP)

FANCM Reaktivität: Human ELISA, IHC (fro), IHC (p) Wirt: Kaninchen Polyclonal HRP
Produktnummer ABIN1711008
  • Target Alle FANCM Antikörper anzeigen
    FANCM (Fanconi Anemia Complementation Group M (FANCM))
    Bindungsspezifität
    • 14
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    AA 831-930
    Reaktivität
    • 32
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 30
    • 2
    • 1
    Kaninchen
    Klonalität
    • 33
    Polyklonal
    Konjugat
    • 14
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser FANCM Antikörper ist konjugiert mit HRP
    Applikation
    • 13
    • 13
    • 11
    • 7
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Homologie
    Human
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human FANCM
    Isotyp
    IgG
    Top Product
    Discover our top product FANCM Primärantikörper
  • Applikationshinweise
    IHC-P 1:200-400
    IHC-F 1:100-500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    FANCM (Fanconi Anemia Complementation Group M (FANCM))
    Andere Bezeichnung
    FANCM (FANCM Produkte)
    Synonyme
    FAAP250 antikoerper, KIAA1596 antikoerper, AI427100 antikoerper, C730036B14Rik antikoerper, D12Ertd364e antikoerper, Fanconi anemia complementation group M antikoerper, hypothetical protein antikoerper, Fanconi anemia, complementation group M antikoerper, FANCM antikoerper, PGTG_17854 antikoerper, Fancm antikoerper
    Hintergrund

    Synonyms: FAAP250, Fanconi anemia group M protein, Protein Hef ortholog,

    Background: Fanconi anemia (FA) is an autosomal recessive disorder characterized by bone marrow failure, birth defects and chromosomal instability. At the cellular level, FA is characterized by spontaneous chromosomal breakage and a unique hypersensitivity to DNA cross-linking agents. The thirteen FA proteins that have been characterized are important for regulating chromosomal stability and genome surveillance. Eight of these proteins, namely FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL and FANCM, comprise the FA core complex, which catalyzes a key reaction in DNA repair: the monoubiquitination of FANCD2. FANCM (Fanconi anemia, complementation group M) is a member of the DEAD-box helicase family of proteins and contains a DEAH helicase domain and a nuclease domain. Localizing to chromatin fractions, FANCM is phosphorylated in a cell cycle-dependent manner and is believed to function as an anchor, recruiting the FA core complex to chromatin. Mutations in the gene encoding FANCM can lead to Fanconi anemia.

    Gen-ID
    57697
    Pathways
    DNA Reparatur
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