APOBEC3C Antikörper (AA 121-190)
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- Target Alle APOBEC3C Antikörper anzeigen
- APOBEC3C (Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3C (APOBEC3C))
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Bindungsspezifität
- AA 121-190
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser APOBEC3C Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)
- Kreuzreaktivität
- Human
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human APOBEC3C
- Isotyp
- IgG
- Top Product
- Discover our top product APOBEC3C Primärantikörper
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- Applikationshinweise
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- APOBEC3C (Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3C (APOBEC3C))
- Andere Bezeichnung
- APOBEC3C (APOBEC3C Produkte)
- Synonyme
- APOBEC3C antikoerper, A3C antikoerper, APOBEC1L antikoerper, ARDC2 antikoerper, ARDC4 antikoerper, ARP5 antikoerper, PBI antikoerper, bK150C2.3 antikoerper, apolipoprotein B mRNA editing enzyme catalytic subunit 3C antikoerper, apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C antikoerper, APOBEC3C antikoerper
- Hintergrund
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Synonyms: ABC3C_HUMAN, APOBEC1 like, APOBEC1-like, APOBEC1L, APOBEC3C, Apolipoprotein B mRNA editing enzyme catalytic polypeptide like 3C, ARDC2, ARDC4, ARP5, bK150C2.3, MGC19485, PBI, Phorbolin I, Phorbolin I protein, Probable DNA dC dU editing enzyme APOBEC 3C, Probable DNA dC->dU-editing enzyme APOBEC-3C.
Background: APOBEC proteins inhibit retroviruses by deaminating cytosine residues of viral RNA and DNA. The seven APOBEC3 genes or pseudogenes are found in a cluster thought to result from gene duplication on chromosome 22. Like APOBEC3G, APOBEC3F deaminates deoxycytosine to deoxyuracil in the minus strand of HIV-1 DNA, resulting in G to A hypermutation in the plus strand of DNA. Thus, APOBEC3G and APOBEC3F provide a mechanism for innate immunity to retroviruses, and are also likely contribute to sequence variation observed in many viruses. Viral infectivity factor (Vif) imparts APOBEC3G and APOBEC3F resistance to HIV through impaired translation of their mRNA and accelerated posttranslational degradation of the APOBEC3 proteins by the 26S proteasome. Interestingly, HIV-1 Vif cannot form a complex with APOBEC3G or APOBEC3F of mouse origin as it does with the human protein, and thus mouse APOBEC3G and APOBEC3F function as a potent inhibitors of wildtype HIV-1 replication, where human APOBEC3G and APOBEC3F are only able to inhibit Vif-deficient HIV-1 replication. This implies that induction of APOBEC3G and APOBEC3F activity or a method of blocking their interaction with Vif may provide a method for therapeutic intervention.
- Gen-ID
- 27350
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