APLF Antikörper (AA 421-511)
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- Target Alle APLF Antikörper anzeigen
- APLF (Aprataxin and PNKP Like Factor (APLF))
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Bindungsspezifität
- AA 421-511
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser APLF Antikörper ist unkonjugiert
- Applikation
- ELISA, Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)
- Homologie
- Human,Mouse,Rat
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human APLF
- Isotyp
- IgG
- Top Product
- Discover our top product APLF Primärantikörper
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- Applikationshinweise
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- APLF (Aprataxin and PNKP Like Factor (APLF))
- Andere Bezeichnung
- APLF (APLF Produkte)
- Synonyme
- apfl antikoerper, palf antikoerper, xip1 antikoerper, APLF antikoerper, C2orf13 antikoerper, DKFZp459J1223 antikoerper, APFL antikoerper, PALF antikoerper, Xip1 antikoerper, 2010301N04Rik antikoerper, AI452191 antikoerper, RGD1565557 antikoerper, aprataxin and PNKP like factor antikoerper, APLF antikoerper, aplf antikoerper, Aplf antikoerper
- Hintergrund
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Synonyms: 2010301N04Rik, AI452191, Aplf, APLF_HUMAN, Aprataxin and pnk-like factor, Apurinic-apyrimidinic endonuclease APLF, C2orf13, PNK and APTX like FHA protein, PNK and APTX-like FHA domain-containing protein, RGD1565557, XIP1, XRCC1 interacting protein 1, XRCC1-interacting protein 1.
Background: APLF is a 511 amino acid protein that contains one FHA doman and two C2H2type zinc fingers. Localized to both the nucleus and the cytoplasm, APLF interacts with XRCC1, XRCC4 and Ku-86 and, via these interactions, is involved in single-strand and double-strand DNA break repair. APLF is subject to post-translational phosphorylation in response to DNA breaks. The gene encoding APLF maps to human chromosome 2, which houses over 1,400 genes and comprises nearly 8 % of the human genome. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene, while the lipid metabolic disorder sitosterolemia is associated with defects in the ABCG5 and ABCG8 genes. Additionally, an extremely rare recessive genetic disorder, is caused by mutations in the ALMS1 gene, which maps to chromosome 2.
- Gen-ID
- 200558
- Pathways
- DNA Reparatur
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