CLCNKB Antikörper (AA 51-150)

Produktnummer ABIN1713748

Produktdetails anti-CLCNKB Antikörper

Target: CLCNKB (Chloride Channel Kb (CLCNKB))

Bindungsspezifität: AA 51-150

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CLCNKB Antikörper ist unkonjugiert

Applikation: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Homologie: Human,Mouse,Rat,Dog,Cow,Pig,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CLCNKB

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu CLCNKB

Target: CLCNKB (Chloride Channel Kb (CLCNKB))

Andere Bezeichnung: CLCNKB (CLCNKB Produkte)

Synonyme: CLCNKA antikoerper, CLCNKB antikoerper, DKFZp469N0132 antikoerper, CLCKB antikoerper, Clc-Ka antikoerper, Clck2 antikoerper, Clcnk1l antikoerper, ClC-K2L antikoerper, ClC-K2 antikoerper, ClC-Kb antikoerper, ClC-k antikoerper, clc-kb antikoerper, clckb antikoerper, clcnka-A antikoerper, clk-k2 antikoerper, x6clck antikoerper, xCIC-K antikoerper, xClC-K antikoerper, zgc:64141 antikoerper, Clcnkb antikoerper, chloride voltage-gated channel Kb antikoerper, chloride channel Kb antikoerper, chloride channel, voltage-sensitive Kb antikoerper, chloride channel, voltage-sensitive Kb L homeolog antikoerper, chloride channel K antikoerper, chloride channel protein ClC-Ka antikoerper, chloride channel protein ClC-Kb antikoerper, CLCNKB antikoerper, Clcnkb antikoerper, clcnkb.L antikoerper, clcnk antikoerper, LOC100017912 antikoerper, LOC100400180 antikoerper, LOC100590605 antikoerper, LOC100730738 antikoerper

Hintergrund:

Synonyms: Bartter syndrome type 3, Chloride channel Kb, Chloride channel kidney B, Chloride channel protein ClC-Kb, Chloride channel voltage sensitive Kb, ClC K2, ClC-K2, ClCK2, CLCKB, CLCKB_HUMAN, CLCNKB, hClC Kb, hClCKb, MGC24087, OTTHUMP00000011120, OTTHUMP00000011121, RP11 5P18.8.

Background: The family of voltage-dependent chloride channels (CLCs) regulate cellular trafficking of chloride ions, a critical component of all living cells. CLCs regulate excitability in muscle and nerve cells, aid in organic solute transport, and maintain cellular volume. CLC-KA is a kidney-specific chloride channel that mediates transepithelial chloride transport in the thin ascending limb of the Henle loop in the inner medulla. CLC-KA plays a crucial role in urine concentration. The gene encoding human CLC-KA maps to chromosome 1p36. Mutations in this gene may be associated with nephrogenic diabetes insipidus in those cases where mutations in the vasopressin V2 receptor and the AQP2 water channel are lacking. CLC-KB mediates basolateral chloride ion efflux in the thick ascending limb and in more distal nephron segments. The gene encoding human CLC-KB maps to chromosome 1p36. Mutations in this gene cause type III Barter?s syndrome which is characterized by renal salt-wasting and low blood pressure.