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SUMO2/3 Antikörper (AA 21-95)

SUMO2/3 Reaktivität: Human WB, FACS, ELISA, IHC (p), IF (cc), IF (p), IHC (fro), ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN1714011
  • Target Alle SUMO2/3 Produkte
    SUMO2/3 (Small Ubiquitin Related Modifier 2/3 (SUMO2/3))
    Bindungsspezifität
    • 15
    • 7
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 21-95
    Reaktivität
    • 48
    • 14
    • 14
    • 1
    • 1
    • 1
    Human
    Wirt
    • 37
    • 10
    • 1
    Kaninchen
    Klonalität
    • 29
    • 19
    Polyklonal
    Konjugat
    • 14
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SUMO2/3 Antikörper ist unkonjugiert
    Applikation
    • 41
    • 23
    • 15
    • 14
    • 13
    • 12
    • 10
    • 6
    • 3
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)
    Kreuzreaktivität
    Human
    Homologie
    Mouse,Rat,Cow,Horse,Chicken,Rabbit,Zebrafish
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Sumo 2+3
    Isotyp
    IgG
  • Applikationshinweise
    WB 1:300-5000
    ELISA 1:500-1000
    FCM 1:20-100
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Haltbarkeit
    12 months
  • Target
    SUMO2/3 (Small Ubiquitin Related Modifier 2/3 (SUMO2/3))
    Andere Bezeichnung
    Sumo 2+3 (SUMO2/3 Produkte)
    Synonyme
    SUMO2 antikoerper, small ubiquitin-like modifier 2 antikoerper, SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)-like antikoerper, small ubiquitin-related modifier 2 antikoerper, SUMO2 antikoerper, LOC711990 antikoerper, LOC714892 antikoerper
    Hintergrund

    Synonyms: HSMT3, MGC117191, OTTHUMP00000115275, OTTHUMP00000115276, OTTHUMP00000115277, Sentrin 2, Small ubiquitin like modier 2, Small ubiquitin like modier protein 3, Small ubiquitin related modier 2, Small ubiquitin related modier 3, SMT3 A, SMT3 B, SMT3 H1, SMT3 H2, SMT3 homolog 1, SMT3 homolog 2, SMT3 homolog, SMT3 suppressor of m two 3 homolog 1, SMT3 suppressor of m two 3 homolog 2 S. cerevisiae, SMT3 suppressor of m two 3 homolog 2, SMT3 suppressor of m two 3 homolog 3 S. cerevisiae, SMT3 suppressor of m two 3 homolog 3, SMT3A, SMT3B, SMT3H1, SMT3H2, Sumo 2, Sumo 3, Sumo2, Sumo3, Suppressor of m two 3 homolog 2, Suppressor of m two 3 homolog 3, Ubiquitin like protein SMT3A, Ubiquitin like protein SMT3B, SUMO2_HUMAN, SUMO3_HUMAN.

    Background: The small ubiquitin-related modifier (SUMO) proteins, which include SUMO-1, SUMO-2 and SUMO-3, belong to the ubiquitin-like protein family. Like ubiquitin, the SUMO proteins are synthesized as precursor proteins that undergo processing before conjugation to target proteins. Also, both utilize the E1, E2, and E3 cascade enzymes for conjugation. However, SUMO and ubiquitin differ with respect to targeting. Ubiquitination predominantly targets proteins for degradation, whereas sumoylation targets proteins to a variety of cellular processing, including nuclear transport, transcriptional regulation, apoptosis and protein stability. The unconjugated SUMO-1, SUMO-2 and SUMO-3 proteins localize to the nuclear membrane, nuclear bodies and cytoplasm, respectively. SUMO-1 utilizes Ubc9 for conjugation to several target proteins, which include IkBa, MDM2, p53, PML and Ran GAP1. SUMO-2 and SUMO-3 contribute to a greater percentage of protein modification than does SUMO-1, and unlike SUMO-1, they can form polymeric chains. In addition, SUMO-3 regulates b-Amyloid generation and may be critical in the onset or progression of Alzheimer?s disease.

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