GSK3 alpha/beta Antikörper (AA 151-250)

Produktnummer ABIN1714094

Produktdetails anti-GSK3 alpha/beta Antikörper

Target: GSK3 alpha/beta (GSK3a/b) (Glycogen Synthase Kinase 3 alpha/beta (GSK3a/b))

Bindungsspezifität: AA 151-250

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GSK3 alpha/beta Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)

Kreuzreaktivität: Ratte

Homologie: Human,Mouse,Dog,Pig,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GSK3 Alpha + Beta

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-GSK3 alpha/beta Antikörper (ABIN1714094)

Freese, Reinhardt, Hefner, Unger, Kirkpatrick, Endres: "A novel blood-brain barrier co-culture system for drug targeting of Alzheimer's disease: establishment by using acitretin as a model drug." in: PLoS ONE, Vol. 9, Issue 3, pp. e91003, (2014) (PubMed).

Details zu GSK3 alpha/beta

Target: GSK3 alpha/beta (GSK3a/b) (Glycogen Synthase Kinase 3 alpha/beta (GSK3a/b))

Andere Bezeichnung: GSK3 Alpha + Beta (GSK3a/b Produkte)

Hintergrund:

Synonyms: Gsk3a, GSK 3 alpha, GSK-3 alpha, GSK3 alpha, Glycogen synthase kinase-3 alpha, GSK 3 alpha, DKFZp686D0638, GSK 3A, GSK3A, GSK3alpha, GSK3A_HUMAN, Glycogen synthase kinase 3 alpha, Serine/threonine-protein kinase GSK3A, Glycogen synthase kinase 3 beta, GSK 3 beta, GSK 3B, GSK3B, GSK3B protein, GSK3beta isoform, GSK3 beta, Glycogen synthase kinase-3 beta, GSK-3 beta, GSK3B_HUMAN, Serine/threonine-protein kinase GSK3B.

Background: The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009].