FZD4 Antikörper (AA 151-250)
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- Target Alle FZD4 Antikörper anzeigen
- FZD4 (Frizzled Family Receptor 4 (FZD4))
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Bindungsspezifität
- AA 151-250
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Reaktivität
- Maus
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser FZD4 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Kreuzreaktivität
- Maus
- Homologie
- Human,Rat,Dog,Cow,Pig,Horse,Chicken
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human Frizzled 4/CD344
- Isotyp
- IgG
- Top Product
- Discover our top product FZD4 Primärantikörper
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- Applikationshinweise
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- FZD4 (Frizzled Family Receptor 4 (FZD4))
- Andere Bezeichnung
- Frizzled 4/CD344 (FZD4 Produkte)
- Synonyme
- CG4626 antikoerper, DFz4 antikoerper, Dfz4 antikoerper, Dm Fz4 antikoerper, Dmel\\CG4626 antikoerper, Fz4 antikoerper, anon-WO0170980.10 antikoerper, anon-WO0170980.11 antikoerper, fz1 antikoerper, zg01 antikoerper, CD344 antikoerper, EVR1 antikoerper, FEVR antikoerper, FZD4S antikoerper, Fz-4 antikoerper, FzE4 antikoerper, GPCR antikoerper, hFz4 antikoerper, frizzled4 antikoerper, fz4 antikoerper, FZ-4 antikoerper, frizzled 4 antikoerper, frizzled class receptor 4 antikoerper, frizzled-4 antikoerper, frizzled class receptor 4 S homeolog antikoerper, fz4 antikoerper, fzd4 antikoerper, Tsp_10376 antikoerper, FZD4 antikoerper, Fzd4 antikoerper, fzd4.S antikoerper
- Hintergrund
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Synonyms: Fz4, EVR1, FEVR, Fz-4, FzE4, GPCR, hFz4, CD344, FZD4S, Frizzled-4, FZD4
Background: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes. Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
- Gen-ID
- 8322
- UniProt
- Q9ULV1
- Pathways
- WNT Signalweg, Hormone Transport, Sensory Perception of Sound
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