FZD3 Antikörper (AA 121-220)
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- Target Alle FZD3 Antikörper anzeigen
- FZD3 (Frizzled Family Receptor 3 (FZD3))
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Bindungsspezifität
- AA 121-220
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Reaktivität
- Human, Maus, Ratte, Xenopus laevis
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser FZD3 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Kreuzreaktivität
- Human, Maus, Ratte
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human FZD3/Frizzled 3
- Isotyp
- IgG
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- Applikationshinweise
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Haltbarkeit
- 12 months
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Deregulation of the planar cell polarity genes CELSR3 and FZD3 in Hirschsprung disease." in: Experimental and molecular pathology, Vol. 101, Issue 2, pp. 241-248, (2016) (PubMed).
: "
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Deregulation of the planar cell polarity genes CELSR3 and FZD3 in Hirschsprung disease." in: Experimental and molecular pathology, Vol. 101, Issue 2, pp. 241-248, (2016) (PubMed).
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- Target
- FZD3 (Frizzled Family Receptor 3 (FZD3))
- Andere Bezeichnung
- FZD3/Frizzled 3 (FZD3 Produkte)
- Synonyme
- Fz-3 antikoerper, FZ-3 antikoerper, fz3 antikoerper, Xfz3 antikoerper, frz3 antikoerper, hfz3 antikoerper, frz-3 antikoerper, frizzled3 antikoerper, frizzled-3 antikoerper, FZD3 antikoerper, AU020229 antikoerper, D930050A07Rik antikoerper, Fz3 antikoerper, fz9 antikoerper, fzd3 antikoerper, zg09 antikoerper, fzd3l antikoerper, frizzled class receptor 3 antikoerper, frizzled class receptor 3 L homeolog antikoerper, frizzled class receptor 3a antikoerper, frizzled class receptor 3b antikoerper, FZD3 antikoerper, fzd3 antikoerper, fzd3.L antikoerper, Fzd3 antikoerper, fzd3a antikoerper, fzd3b antikoerper
- Hintergrund
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Synonyms: Fz-3, Frizzled-3, hFz3, FZD3
Background: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
- Gen-ID
- 7976
- UniProt
- Q9NPG1
- Pathways
- WNT Signalweg, Tube Formation
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