HIC1 Antikörper (AA 501-650)

Produktnummer ABIN1714195

Produktdetails anti-HIC1 Antikörper

Target: HIC1 (Hypermethylated in Cancer 1 (HIC1))

Bindungsspezifität: AA 501-650

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HIC1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Kreuzreaktivität: Maus

Homologie: Human,Rat,Dog,Cow,Pig,Horse,Chicken

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human HIC1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-HIC1 Antikörper (ABIN1714195)

Li, Yao, Wu, Zhang, Wang, Chen, Fu, Weng, Wang: "Loss of hypermethylated in cancer 1 (HIC1) promotes lung cancer progression." in: Cellular signalling, Vol. 53, pp. 162-169, (2019) (PubMed).

Details zu HIC1

Target: HIC1 (Hypermethylated in Cancer 1 (HIC1))

Andere Bezeichnung: HIC1 (HIC1 Produkte)

Synonyme: zfHIC1 antikoerper, HIC1 antikoerper, ZBTB29 antikoerper, ZNF901 antikoerper, hic-1 antikoerper, AA408311 antikoerper, HIC-1 antikoerper, hypermethylated in cancer 1 antikoerper, HIC ZBTB transcriptional repressor 1 antikoerper, hic1 antikoerper, HIC1 antikoerper, Hic1 antikoerper

Hintergrund:

Synonyms: Hic 1, Hic-1, Hic1, HIC1_HUMAN, Hypermethylated in cancer 1, Hypermethylated in cancer 1 protein, ZBTB29, Zinc finger and BTB domain-containing protein 29, ZNF901.

Background: Hypermethylated in cancer (HIC-1) was originally identified as a target of p53-induced gene expression. HIC-1 is deleted in the genetic disorder Miller-Dieker syndrome (MDS), and the expression of HIC-1 is also frequently suppressed in leukemia and various cancers due to the hypermethylation of specific DNA regions and the resulting transcriptional silencing. These and other studies indicate that HIC-1 acts as a putative tumor suppressor protein that mediates transcriptional repression. HIC-1 is ubiquitously expressed in adult tissues and its structure is defined by five zinc fingers and an N-terminal broad complex POZ (or BTB) domain. In several BTB/POZ containing proteins, including BCL-6 and the promyelocytic leukemia zinc-finger (PLZF) oncoprotein, this domain interacts with the SMRT/N-CoR-mSin3A HDAC complex and is directly involved in repressing and silencing gene transcription. When this domain is deleted, as with the oncogenic PLZF-RAR chimera of promyelocytic leukemias, this transcriptional repression is attenuated. Conversely, HIC-1 does not interact with components of the HDAC complex, suggesting that HIC-1-induced transcriptional repression is unassociated with the POZ/BTB domain.

Gen-ID: 3090

Pathways: Positive Regulation of Response to DNA Damage Stimulus