GCS1 Antikörper (AA 51-150)

Produktnummer ABIN1714454

Produktdetails anti-GCS1 Antikörper

Target: GCS1 (MOGS) (Mannosyl-Oligosaccharide Glucosidase (MOGS))

Bindungsspezifität: AA 51-150

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GCS1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Homologie: Human,Mouse,Rat,Dog

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GCS1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu GCS1

Target: GCS1 (MOGS) (Mannosyl-Oligosaccharide Glucosidase (MOGS))

Andere Bezeichnung: GCS1 (MOGS Produkte)

Synonyme: Afu6g04210 antikoerper, AO090701000141 antikoerper, Mogs antikoerper, CDG2B antikoerper, CWH41 antikoerper, DER7 antikoerper, GCS1 antikoerper, 1810017N02Rik antikoerper, AI181835 antikoerper, Gcs1 antikoerper, gcs1 antikoerper, im:7160827 antikoerper, wu:fe50a12 antikoerper, wu:fk09a10 antikoerper, zgc:158312 antikoerper, mannosyl-oligosaccharide glucosidase antikoerper, mannosyl-oligosaccharide glucosidase GCS1 antikoerper, mannosyl-oligosaccharide glucosidase L homeolog antikoerper, mannosyl oligosaccharide glucosidase antikoerper, glucosidase 1 antikoerper, AFUA_6G04210 antikoerper, Tc00.1047053511015.10 antikoerper, Tc00.1047053511805.10 antikoerper, LOC5576381 antikoerper, AOR_1_260114 antikoerper, MGYG_00305 antikoerper, TERG_01248 antikoerper, mogs.L antikoerper, TTHERM_00636930 antikoerper, LOAG_03690 antikoerper, Gcs1 antikoerper, MOGS antikoerper, Mogs antikoerper, mogs antikoerper

Hintergrund:

Synonyms: EC 3.2.1.106, glucosidase I, Mannosyl oligosaccharide glucosidase, Mannosyl-oligosaccharide glucosidase, Mogs, MOGS_HUMAN, Processing A glucosidase I, Processing A-glucosidase I.

Background: Glycosylation of asparagine residues in Asn-X-Ser/Thr motifs in proteins commonly occur in the lumen of the endoplasmic reticulum (ER). Glucosidase I catalyzes the first step in the N-linked oligosaccharide processing pathway. It specifically removes the distal alpha 1,2-linked glucose residue from the Glc3-Man9-GlcNAc2 oligosaccharide precursor. Glucosidase I contains a short cytosolic tail, a single pass transmembrane domain and a large C-terminal catalytic domain located on the luminal side of the ER. Mutations in the gene encoding Glucosidase I result in the congenital disorder glycosylation (CDG-IIb), which is characterized by generalized hypotonia, dysmorphic features, hepatomegaly, hypoventilation, feeding problems, seizures and death. Two point mutations in the Glucosidase I gene have been identified and result in amino acid substitutions, namely Arg486Thr and Phe652Leu, that affect polypeptide folding and active site formation.

Gen-ID: 7841

Pathways: SARS-CoV-2 Protein Interaktom