Complement Component C9b (C9b) (AA 251-350) Antikörper

Produktnummer ABIN1714714

Produktdetails

Target: Complement Component C9b (C9b)

Bindungsspezifität: AA 251-350

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität: Human, Maus

Homologie: Rat,Dog,Cow,Sheep,Pig

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Complement component C9b

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen

Pauly, Agarwal, Dana, Schäfer, Biber, Wunderlich, Jabri, Straub, Zhang, Gautam, Weber, Hauck, Kim, Curcio, Stambolian, Li, Grosche: "Cell-Type-Specific Complement Expression in the Healthy and Diseased Retina." in: Cell reports, Vol. 29, Issue 9, pp. 2835-2848.e4, (2019) (PubMed).

Antigendetails

Target: Complement Component C9b (C9b)

Andere Bezeichnung: Complement component C9b (C9b Produkte)

Synonyme: C9 antikoerper, complement C9 antikoerper, proteasome (prosome, macropain) subunit, alpha type 4 antikoerper, C9 antikoerper, Psma4 antikoerper

Hintergrund:

Synonyms: CO9_HUMAN, Complement component C9, Complementcomponent C9b.

Background: C9 is a plasma protein synthesized in the liver and monocytes consisting of a single polypeptide chain. C9 is a part of the membrane attack complex (MAC), an important component of the immune system. The MAC forms upon complement system activation by invading pathogenic bacteria and consists of the four major complement proteins: C5b, C6, C7 and C8. These complement proteins bind to the outer surface of the plasma membrane of the invading cell. C9 binds to the membrane associated C5b-8 protein, which leads to the circular polymerization of 12-18 C9 Molecules. These polymerized C9 Molecules form a ring structure in the membrane. Molecules can then diffuse freely through this transmembrane channel, causing cell lysis and destruction of the invading bacterial cell.

Gen-ID: 735