EXOSC10 Antikörper (AA 41-140)

Produktnummer ABIN1714746

Produktdetails anti-EXOSC10 Antikörper

Target: EXOSC10 (Exosome Component 10 (EXOSC10))

Bindungsspezifität: AA 41-140

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EXOSC10 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)

Kreuzreaktivität: Human, Maus

Homologie: Rat,Dog,Cow,Sheep,Pig,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human EXOSC10/PMSCL2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu EXOSC10

Target: EXOSC10 (Exosome Component 10 (EXOSC10))

Andere Bezeichnung: EXOSC10/PMSCL2 (EXOSC10 Produkte)

Synonyme: Pmscl2 antikoerper, zgc:55695 antikoerper, pm-scl antikoerper, pm/scl-100 antikoerper, pmscl antikoerper, pmscl2 antikoerper, rrp6 antikoerper, rrp6p antikoerper, EXOSC10 antikoerper, 201.t00018 antikoerper, 21.m02990 antikoerper, DDBDRAFT_0203581 antikoerper, DDBDRAFT_0233752 antikoerper, DDB_0203581 antikoerper, DDB_0233752 antikoerper, PM-Scl antikoerper, PM/Scl-100 antikoerper, PMSCL antikoerper, PMSCL2 antikoerper, RRP6 antikoerper, Rrp6p antikoerper, p2 antikoerper, p3 antikoerper, p4 antikoerper, exosome component 10 antikoerper, 3'-5' exonuclease antikoerper, exosome component 10 L homeolog antikoerper, exosc10 antikoerper, EXOSC10 antikoerper, EHI_021400 antikoerper, BBOV_IV002650 antikoerper, CpipJ_CPIJ003896 antikoerper, CMU_031760 antikoerper, Tsp_05247 antikoerper, exosc10.L antikoerper, Exosc10 antikoerper

Hintergrund:

Synonyms: Autoantigen PM/Scl 2, Exosc10, Exosome component 10, EXOSX_HUMAN, P100 polymyositis scleroderma overlap syndrome associated autoantigen, P100 polymyositis-scleroderma overlap syndrome-associated autoantigen, p2, p3, p4, PM Scl, PM/Scl 100, PM/Scl-100, PMSCL, PMSCL2, Polymyositis/scleroderma autoantigen 100 kDa, Polymyositis/scleroderma autoantigen 2 100 kDa, Polymyositis/scleroderma autoantigen 2, RRP6, Rrp6p.

Background: The exosome is a multi-subunit complex composed of several highly conserved proteins, some of which are 3? to 5? exoribonucleases. The complex is involved in a variety of cellular processes and is responsible for degrading unstable mRNAs that contain AU-rich (ARE) elements in their untranslated 3? region. EXOSC10, also known as PMSCL, PMSCL2, p2, p3, p4, RRP6, Rrp6p, PM-Scl, or PM/Scl-100, is an 885 amino acid protein that contains one HRDC domain and one 3?-5? enonuclease domain. Localized to both the cytoplasm and the nucleus, EXOSC10 is part of the post-splicing exosome complex and is involved in mRNA surveillance, mRNA nuclear export and nonsense-mediated decay of mRNAs containing premature stop codons. against EXOSC10 have been found in patients with scleroderma and/or polymyositis (chronic diseases of the skin and muscle, respectively), suggesting that EXOSC10 may be involved in the pathogenesis of these diseases. Two isoforms of EXOSC10 exist due to alternative splicing events.

Gen-ID: 5394