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Hephaestin Antikörper (AA 21-120)

HEPH Reaktivität: Human, Maus WB, ELISA, IF (p), IF (cc), ICC, IHC (fro), IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN1715088
  • Target Alle Hephaestin (HEPH) Antikörper anzeigen
    Hephaestin (HEPH)
    Bindungsspezifität
    • 14
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 21-120
    Reaktivität
    • 24
    • 18
    • 5
    Human, Maus
    Wirt
    • 22
    • 3
    Kaninchen
    Klonalität
    • 24
    • 2
    Polyklonal
    Konjugat
    • 12
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Hephaestin Antikörper ist unkonjugiert
    Applikation
    • 24
    • 12
    • 12
    • 9
    • 7
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Kreuzreaktivität
    Human, Maus
    Homologie
    Rat
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Hephaestin
    Isotyp
    IgG
    Top Product
    Discover our top product HEPH Primärantikörper
  • Applikationshinweise
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Haltbarkeit
    12 months
  • Rychtarcikova, Lettlova, Tomkova, Korenkova, Langerova, Simonova, Zjablovskaja, Alberich-Jorda, Neuzil, Truksa: "Tumor-initiating cells of breast and prostate origin show alterations in the expression of genes related to iron metabolism." in: Oncotarget, Vol. 8, Issue 4, pp. 6376-6398, (2016) (PubMed).

  • Target
    Hephaestin (HEPH)
    Andere Bezeichnung
    Hephaestin (HEPH Produkte)
    Synonyme
    HEPH antikoerper, C130006F04Rik antikoerper, Cpl antikoerper, mKIAA0698 antikoerper, sla antikoerper, CPL antikoerper, hephaestin antikoerper, HEPH antikoerper, heph antikoerper, Heph antikoerper
    Hintergrund

    Synonyms: CPL, HEPH, HEPH_HUMAN, Hephaestin.

    Background: Hephaestin is a single-pass type I membrane protein that belongs to the multicopper oxidase family of proteins. Hephaestin, a copper-dependant ferroxidase protein, is crucial for iron exiting intestinal enterocytes into the circulation. It mediates the movement of iron across the basolateral membrane in conjunction with ferroportin 1. This is an important link between iron and copper metabolism in mammalian systems, as copper deficiency leads to reduced hephaestin and reduced iron absorption resulting in anemia. Hephaestin can bind six copper ions per monomer and is regulated by the homeobox transcription factor CDX2. Increased levels of iron leads to an increase in CDX2 expression and thus Hephaestin. Hephaestin is primarily detected in the intestine, but is also expressed in colon, breast, bone trabecural cells and fibroblasts.

    Gen-ID
    9843
    Pathways
    Transition Metal Ion Homeostasis
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