p53 Antikörper
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- Target Alle p53 (TP53) Antikörper anzeigen
- p53 (TP53) (Tumor Protein P53 (TP53))
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser p53 Antikörper ist unkonjugiert
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Applikation
- ELISA (Capture)
- Spezifität
- Reacts with wild type and mutant p53, the epitope is within residues 18-30 of human p53
- Aufreinigung
- Purified
- Immunogen
- Recombinant p53 protein
- Klon
- B-F34
- Isotyp
- IgG2b
- Top Product
- Discover our top product TP53 Primärantikörper
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- Applikationshinweise
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Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
ELISA-C1 - 5 μg/mL - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- PBS, Sterile-filtered through 0.22 μm Carrier and Preservative free
- Konservierungsmittel
- Without preservative
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- Short term storage at+4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 months from date of receipt.
- Haltbarkeit
- 6 months
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- Target
- p53 (TP53) (Tumor Protein P53 (TP53))
- Andere Bezeichnung
- p53 (TP53 Produkte)
- Hintergrund
- Acts as a tumor suppressor in many tumor types, induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis, the function is largely independent of transcription.
- Gen-ID
- 7157
- UniProt
- P04637
- Pathways
- p53 Signalweg, MAPK Signalweg, PI3K-Akt Signalweg, Apoptose, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagie, Warburg Effekt
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