MYST1 Antikörper

Produktnummer ABIN1724671

Produktdetails anti-MYST1 Antikörper

Target: MYST1 (KAT8) (K(lysine) Acetyltransferase 8 (KAT8))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MYST1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Verwendungszweck: MYST1 Antibody

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of human MYST1 expressed in E. Coli.

Klon: 8C4C4

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-MYST1 Antikörper (ABIN1724671)

Jiang, Gao, Zheng, Yin, Wang, Zhong, Ali, Khan, Hao, Fang, Sun, Xu, Pandita, Jiang, Shi: "MOF influences meiotic expansion of H2AX phosphorylation and spermatogenesis in mice." in: PLoS genetics, Vol. 14, Issue 5, pp. e1007300, (2018) (PubMed).

Akhtar, Becker: "The histone H4 acetyltransferase MOF uses a C2HC zinc finger for substrate recognition." in: EMBO reports, Vol. 2, Issue 2, pp. 113-8, (2001) (PubMed).

Neal, Pannuti, Smith, Lucchesi: "A new human member of the MYST family of histone acetyl transferases with high sequence similarity to Drosophila MOF." in: Biochimica et biophysica acta, Vol. 1490, Issue 1-2, pp. 170-4, (2000) (PubMed).

Sterner, Berger: "Acetylation of histones and transcription-related factors." in: Microbiology and molecular biology reviews : MMBR, Vol. 64, Issue 2, pp. 435-59, (2000) (PubMed).

Details zu MYST1

Target: MYST1 (KAT8) (K(lysine) Acetyltransferase 8 (KAT8))

Andere Bezeichnung: MYST1 (KAT8 Produkte)

Hintergrund:

Description: MYST1 (MYST histone acetyltransferase 1, MOF) belongs to the MYST family of histone acetyltransferases, which are employed in the cell to bring about transcriptional regulation. The MYST family includes MYST1, is named for the founding members MOZ, yeast YBF2 and SAS2, and TIP60. All members of this family contain a MYST region of about 240 amino acids with a canonical acetyl-CoA-binding site and a C2HC-type zinc finger motif. Most MYST proteins also have a chromodomain involved in protein- protein interactions and targeting transcriptional regulators to chromatin. Although MOF is expressed in both males and females, it associates with the X chromosome only in males. MOF contains a zinc-finger domain that is used to contact the globular part of the nucleosome and histone H4. The carboxy terminal domain of human MOF also has histone acetyltransferase activity directed against histones H3 and H2A, a characteristic shared with other MYST family histone

Aliases: MOF, KAT8, hMOF

Molekulargewicht: 53kDa

Gen-ID: 84148

HGNC: 84148

UniProt: Q9H7Z6