SYK Antikörper (AA 296-484)
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- Target Alle SYK Antikörper anzeigen
- SYK (Spleen tyrosine Kinase (SYK))
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Bindungsspezifität
- AA 296-484
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser SYK Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA
- Aufreinigung
- purified
- Immunogen
- Purified recombinant fragment of SYK (aa296-484) expressed in E. coli.
- Klon
- 8C1A3
- Isotyp
- IgG1
- Top Product
- Discover our top product SYK Primärantikörper
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- Applikationshinweise
- ELISA: 1:10000, WB: 1:500 - 1:2000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- Ascitic fluid containing 0.03 % sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- 4°C, -20°C for long term storage
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Lipid raft adhesion receptors and Syk regulate selectin-dependent rolling under flow conditions." in: Blood, Vol. 108, Issue 10, pp. 3352-9, (2006) (PubMed).
: "Promoter hypermethylation of the 14-3-3 sigma, SYK and CAGE-1 genes is related to the various phenotypes of urinary bladder carcinomas and associated with progression of transitional cell carcinomas." in: International journal of molecular medicine, Vol. 18, Issue 4, pp. 547-57, (2006) (PubMed).
: "Deregulated Syk inhibits differentiation and induces growth factor-independent proliferation of pre-B cells." in: The Journal of experimental medicine, Vol. 203, Issue 13, pp. 2829-40, (2006) (PubMed).
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Lipid raft adhesion receptors and Syk regulate selectin-dependent rolling under flow conditions." in: Blood, Vol. 108, Issue 10, pp. 3352-9, (2006) (PubMed).
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- Target
- SYK (Spleen tyrosine Kinase (SYK))
- Andere Bezeichnung
- SYK (SYK Produkte)
- Synonyme
- p72-Syk antikoerper, Sykb antikoerper, p72syk antikoerper, spleen associated tyrosine kinase antikoerper, spleen tyrosine kinase antikoerper, syk antikoerper, SYK antikoerper, Syk antikoerper
- Hintergrund
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Description: SYK: spleen tyrosine kinase. Syk (72 kDa) is a non-receptor protein tyrosine kinase that plays an important role in immune receptor signal transduction and is implicated in endothelial cell functions, including cell growth and migration. SYK is a positive effector of BCR stimulated responses. It couples the B cell antigen receptor (BCR) to the mobilization of calcium ions either through a phosphoinositide 3 kinase dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C gamma dependent pathway, when phosphorylated on Tyr 342 and Tyr 346. Thus the differential phosphorylation of SYK can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ions.
Aliases: FLJ25043, FLJ37489, DKFZp313N1010
- Gen-ID
- 6580
- HGNC
- 6580
- Pathways
- Fc-epsilon Rezeptor Signalübertragung, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Thromboxane A2 Receptor Signaling, BCR Signaling
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