RCHY1 Antikörper
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- Target Alle RCHY1 Antikörper anzeigen
- RCHY1 (Ring Finger and CHY Zinc Finger Domain Containing 1, E3 Ubiquitin Protein Ligase (RCHY1))
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Reaktivität
- Human, Ratte
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser RCHY1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC)
- Aufreinigung
- purified
- Immunogen
- Purified recombinant fragment of human Pirh2 expressed in E. coli.
- Klon
- 1H10
- Isotyp
- IgG1
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- Applikationshinweise
- ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: 1:200 - 1:1000, FCM: 1:200 - 1:400
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- Ascitic fluid containing 0.03 % sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- 4°C, -20°C for long term storage
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Differential response between the p53 ubiquitin-protein ligases Pirh2 and MdM2 following DNA damage in human cancer cells." in: Experimental cell research, Vol. 312, Issue 17, pp. 3370-8, (2006) (PubMed).
: "Expression of Pirh2, a newly identified ubiquitin protein ligase, in lung cancer." in: Journal of the National Cancer Institute, Vol. 96, Issue 22, pp. 1718-21, (2004) (PubMed).
: "
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Differential response between the p53 ubiquitin-protein ligases Pirh2 and MdM2 following DNA damage in human cancer cells." in: Experimental cell research, Vol. 312, Issue 17, pp. 3370-8, (2006) (PubMed).
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- Target
- RCHY1 (Ring Finger and CHY Zinc Finger Domain Containing 1, E3 Ubiquitin Protein Ligase (RCHY1))
- Andere Bezeichnung
- Pirh2 (RCHY1 Produkte)
- Synonyme
- ARNIP antikoerper, CHIMP antikoerper, PIRH2 antikoerper, PRO1996 antikoerper, RNF199 antikoerper, ZNF363 antikoerper, Pirh2 antikoerper, Zfp363 antikoerper, Znf363 antikoerper, wu:fb37e07 antikoerper, zgc:101128 antikoerper, RCHY1 antikoerper, arnip antikoerper, chimp antikoerper, pirh2 antikoerper, harnip antikoerper, rnf199 antikoerper, znf363 antikoerper, pro1996 antikoerper, ring finger and CHY zinc finger domain containing 1 antikoerper, ring finger and CHY zinc finger domain containing 1 L homeolog antikoerper, RCHY1 antikoerper, Rchy1 antikoerper, rchy1 antikoerper, rchy1.L antikoerper
- Hintergrund
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Description: Pirh 2 (P53 induced RING-H2 protein), also known as RCHY1, it forms dimers through its N- and C-terminus in cells. The Pirh2 has ubiquitin-protein ligase activity and it binds with p53 and promotes the ubiquitin-mediated proteosomal degradation of p53. The Pirh2 is oncogenic because loss of p53 function contributes directly to malignant tumor development. Pirh2 expression decreases the level of p53, and a decrease of endogenous Pirh2 expression increases p53 levels. Pirh2 is therefore considered, together with MDM2, to act as a negative regulator of p53 function.
Aliases: ARNIP, CHIMP, RNF199, RCHY1
- Molekulargewicht
- 30 kDa, 60 kDa (homodimer)
- Gen-ID
- 25898
- HGNC
- 25898
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