ERK1/2 Antikörper
(1 reference)-
- Target Alle ERK1/2 (MAPK1/3) Antikörper anzeigen
- ERK1/2 (MAPK1/3) (Mitogen-Activated Protein Kinase 1/3 (MAPK1/3))
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser ERK1/2 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)
- Verwendungszweck
- p44/42 MAPK (Erk1/2) Antibody
- Aufreinigung
- Ascitic fluid
- Immunogen
- Purified recombinant fragment of human MAPK expressed in E. Coli.
- Klon
- 3F8
- Isotyp
- IgG2b
- Top Product
- Discover our top product MAPK1/3 Primärantikörper
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anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (AA 301-358) antibody
MAPK1/3 Reaktivität: Human, Maus, Ratte, Schwein WB, ELISA, IHC (p), IF (cc), FACS, IF (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) antibodyMAPK1/3 Reaktivität: Human, Maus, Ratte, Rind (Kuh), Schwein, Zebrafisch (Danio rerio), Hund, Schaf, Fisch, Pferd, Affe WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (AA 300-380) antibodyMAPK1/3 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC (p), IF Wirt: Kaninchen Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (pThr202), (pTyr204) antibodyMAPK1/3 Reaktivität: Human, Maus, Ratte, Rind (Kuh) WB, ELISA, IHC (p), IF (cc), FACS, IF (p), IHC (fro), ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (pThr183), (pTyr185) antibodyMAPK1/3 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (pThr185), (pThr202) antibodyMAPK1/3 Reaktivität: Human WB, IHC Wirt: Kaninchen Monoclonal unconjugated
anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (C-Term) antibodyMAPK1/3 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (pThr183), (pTyr185) antibodyMAPK1/3 Reaktivität: Human, Maus, Ratte, Huhn WB, ELISA, IHC (p), IF (cc), FACS, IF (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (pThr202), (pTyr204) antibodyMAPK1/3 Reaktivität: Human WB, DB Wirt: Kaninchen Polyclonal RB15981 unconjugated
anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) antibodyMAPK1/3 Reaktivität: Human, Maus WB, FACS Wirt: Maus Monoclonal 784CT7-6-3 unconjugated
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- Applikationshinweise
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ELISA: 1/10000
FCM: 1/200 - 1/400
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- Ascitic fluid containing 0.03 % sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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: "Protein kinase Cdelta supports survival of MDA-MB-231 breast cancer cells by suppressing the ERK1/2 pathway." in: The Journal of biological chemistry, Vol. 284, Issue 48, pp. 33456-65, (2009) (PubMed).
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: "Protein kinase Cdelta supports survival of MDA-MB-231 breast cancer cells by suppressing the ERK1/2 pathway." in: The Journal of biological chemistry, Vol. 284, Issue 48, pp. 33456-65, (2009) (PubMed).
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- Target
- ERK1/2 (MAPK1/3) (Mitogen-Activated Protein Kinase 1/3 (MAPK1/3))
- Andere Bezeichnung
- p44/42 MAPK (Erk1/2) (MAPK1/3 Produkte)
- Synonyme
- erk1/2 antikoerper, mitogen-activated protein kinase antikoerper, erk1/2 antikoerper
- Hintergrund
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Description: Mitogen-activated protein kinases (MAPKs) are a widely conserved family of serine/threonine protein kinases involved in many cellular programs such as cell proliferation, differentiation, motility, and death. The p44/42 MAPK (Erk1/2) signaling pathway can be activated in response to a diverse range of extracellular stimuli including mitogens, growth factors, and cytokines and is an important target in the diagnosis and treatment of cancer. Upon stimulation, a sequential three-part protein kinase cascade is initiated, consisting of a MAP kinase kinase kinase (MAPKKK or MAP3K), a MAP kinase kinase (MAPKK or MAP2K), and a MAP kinase (MAPK). Multiple p44/42 MAP3Ks have been identified, including members of the Raf family as well as Mos and Tpl2/Cot. MEK1 and MEK2 are the primary MAPKKs in this pathway. MEK1 and MEK2 activate p44 and p42 through phosphorylation of activation loop residues Thr202/Tyr204 and Thr185/Tyr187, respectively. Several downstream targets of p44/42 have been identified, including p90RSK and the transcription factor Elk-1. p44/42 are negatively regulated by a family of dual-specificity (Thr/Tyr) MAPK phosphatases, known as DUSPs or MKPs, along with MEK inhibitors such as U0126 and PD98059.
Aliases: ERK, p38, p40, p41, ERK2, ERT1, MAPK2, PRKM1, PRKM2, P42MAPK, p41mapk, MAPK1
- Molekulargewicht
- 42kDa
- Gen-ID
- 5594
- HGNC
- 5594
- UniProt
- P28482
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