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PCNA Antikörper (AA 53-196)

PCNA Reaktivität: Human WB, IHC, ELISA, FACS Wirt: Maus Monoclonal 7H4F8 unconjugated
Produktnummer ABIN1724759
  • Target Alle PCNA Antikörper anzeigen
    PCNA (Proliferating Cell Nuclear Antigen (PCNA))
    Bindungsspezifität
    • 16
    • 16
    • 16
    • 15
    • 12
    • 11
    • 8
    • 6
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 53-196
    Reaktivität
    • 212
    • 153
    • 152
    • 54
    • 28
    • 27
    • 21
    • 19
    • 19
    • 18
    • 17
    • 15
    • 11
    • 10
    • 6
    • 6
    • 5
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 130
    • 95
    • 3
    Maus
    Klonalität
    • 129
    • 98
    • 1
    Monoklonal
    Konjugat
    • 111
    • 17
    • 13
    • 8
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser PCNA Antikörper ist unkonjugiert
    Applikation
    • 190
    • 68
    • 64
    • 59
    • 53
    • 48
    • 47
    • 40
    • 31
    • 15
    • 15
    • 12
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)
    Verwendungszweck
    PCNA Antibody
    Aufreinigung
    Ascitic fluid
    Immunogen
    Purified recombinant fragment of human PCNA (AA: 53-196 ) expressed in E. Coli.
    Klon
    7H4F8
    Isotyp
    IgG1
    Top Product
    Discover our top product PCNA Primärantikörper
  • Applikationshinweise

    ELISA: 1/10000

    FCM: 1/200 - 1/400

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Ascitic fluid containing 0.03 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Takawa, Cho, Hayami, Toyokawa, Kogure, Yamane, Iwai, Maejima, Ueda, Masuda, Dohmae, Field, Tsunoda, Kobayashi, Akasu, Sugiyama, Ohnuma, Atomi, Ponder, Nakamura, Hamamoto: "Histone lysine methyltransferase SETD8 promotes carcinogenesis by deregulating PCNA expression." in: Cancer research, Vol. 72, Issue 13, pp. 3217-27, (2012) (PubMed).

    Zhao, Ho, Lo, Espejo, Bedford, Hung, Wang: "Interaction of proliferation cell nuclear antigen (PCNA) with c-Abl in cell proliferation and response to DNA damages in breast cancer." in: PLoS ONE, Vol. 7, Issue 1, pp. e29416, (2012) (PubMed).

  • Target
    PCNA (Proliferating Cell Nuclear Antigen (PCNA))
    Andere Bezeichnung
    PCNA (PCNA Produkte)
    Hintergrund
    The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome.

    Molekulargewicht
    28.7kDa
    Gen-ID
    5111
    HGNC
    5111
    UniProt
    P12004
    Pathways
    Telomere Maintenance, DNA Reparatur, Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Autophagie
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