ALDH2 Antikörper (AA 317-517)

Produktnummer ABIN1724795

Produktdetails anti-ALDH2 Antikörper

Target: ALDH2 (Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2))

Bindungsspezifität: AA 317-517

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ALDH2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)

Verwendungszweck: ALDH2 Antibody

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of human ALDH2 (AA: 317-517) expressed in E. Coli.

Klon: 4G6A3

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/150

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-ALDH2 Antikörper (ABIN1724795)

Zhang, Gong, Zhang, Li, Hu: "Effect of mitochondrial aldehyde dehydrogenase-2 genotype on cardioprotection in patients with congenital heart disease." in: European heart journal, Vol. 33, Issue 13, pp. 1606-14, (2012) (PubMed).

Bae, Kim, Shin, Kim, Shin, Kim, Kim, Yoon: "The acute effects of ethanol and acetaldehyde on physiological responses after ethanol ingestion in young healthy men with different ALDH2 genotypes." in: Clinical toxicology (Philadelphia, Pa.), Vol. 50, Issue 4, pp. 242-9, (2012) (PubMed).

Details zu ALDH2

Target: ALDH2 (Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2))

Andere Bezeichnung: ALDH2 (ALDH2 Produkte)

Synonyme: aldh2 antikoerper, aldh2a antikoerper, zgc:63786 antikoerper, MGC80785 antikoerper, aldh-e2 antikoerper, aldhi antikoerper, aldm antikoerper, rf2b antikoerper, ALDH-E2 antikoerper, ALDHI antikoerper, ALDM antikoerper, Ahd-5 antikoerper, Ahd5 antikoerper, aldehyde dehydrogenase 2 family (mitochondrial), tandem duplicate 1 antikoerper, aldehyde dehydrogenase 2 family (mitochondrial) L homeolog antikoerper, aldehyde dehydrogenase 2 family (mitochondrial) antikoerper, aldehyde dehydrogenase 2 antikoerper, aldehyde dehydrogenase antikoerper, aldehyde dehydrogenase (NAD(+)) antikoerper, hypothetical protein antikoerper, aldehyde dehydrogenase 2, mitochondrial antikoerper, aldh2.1 antikoerper, aldh2.L antikoerper, aldh2 antikoerper, ALDH2 antikoerper, RHA1_RS43090 antikoerper, aldH2 antikoerper, OE_RS03015 antikoerper, Aldh2 antikoerper

Hintergrund:

Description: This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50 % of Orientals have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Aliases: ALDM, ALDHI, ALDH-E2

Molekulargewicht: 56.3kDa

Gen-ID: 217

HGNC: 217

UniProt: P05091