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ALDH2 Antikörper (AA 317-517)

ALDH2 Reaktivität: Human, Maus, Ratte WB, IHC, ELISA, FACS, ICC Wirt: Maus Monoclonal 4G6A3 unconjugated
Produktnummer ABIN1724795
  • Target Alle ALDH2 Antikörper anzeigen
    ALDH2 (Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2))
    Bindungsspezifität
    • 10
    • 8
    • 8
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 317-517
    Reaktivität
    • 77
    • 20
    • 18
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 58
    • 17
    • 2
    Maus
    Klonalität
    • 58
    • 19
    Monoklonal
    Konjugat
    • 36
    • 10
    • 5
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser ALDH2 Antikörper ist unkonjugiert
    Applikation
    • 62
    • 42
    • 39
    • 17
    • 13
    • 11
    • 7
    • 3
    • 2
    • 2
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)
    Aufreinigung
    purified
    Immunogen
    Purified recombinant fragment of human ALDH2 (AA: 317-517) expressed in E. coli.
    Klon
    4G6A3
    Isotyp
    IgG1
  • Applikationshinweise
    ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: 1:150, FCM: 1:200 - 1:400
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Ascitic fluid containing 0.03 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    4°C, -20°C for long term storage
  • Zhang, Gong, Zhang, Li, Hu: "Effect of mitochondrial aldehyde dehydrogenase-2 genotype on cardioprotection in patients with congenital heart disease." in: European heart journal, Vol. 33, Issue 13, pp. 1606-14, (2012) (PubMed).

    Bae, Kim, Shin, Kim, Shin, Kim, Kim, Yoon: "The acute effects of ethanol and acetaldehyde on physiological responses after ethanol ingestion in young healthy men with different ALDH2 genotypes." in: Clinical toxicology (Philadelphia, Pa.), Vol. 50, Issue 4, pp. 242-9, (2012) (PubMed).

  • Target
    ALDH2 (Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2))
    Andere Bezeichnung
    ALDH2 (ALDH2 Produkte)
    Synonyme
    aldh2 antikoerper, aldh2a antikoerper, zgc:63786 antikoerper, MGC80785 antikoerper, aldh-e2 antikoerper, aldhi antikoerper, aldm antikoerper, rf2b antikoerper, ALDH-E2 antikoerper, ALDHI antikoerper, ALDM antikoerper, Ahd-5 antikoerper, Ahd5 antikoerper, aldehyde dehydrogenase 2 family (mitochondrial), tandem duplicate 1 antikoerper, aldehyde dehydrogenase 2 family (mitochondrial) L homeolog antikoerper, aldehyde dehydrogenase 2 family (mitochondrial) antikoerper, aldehyde dehydrogenase 2 antikoerper, aldehyde dehydrogenase antikoerper, aldehyde dehydrogenase (NAD(+)) antikoerper, hypothetical protein antikoerper, aldehyde dehydrogenase 2, mitochondrial antikoerper, aldh2.1 antikoerper, aldh2.L antikoerper, aldh2 antikoerper, ALDH2 antikoerper, RHA1_RS43090 antikoerper, aldH2 antikoerper, OE_RS03015 antikoerper, Aldh2 antikoerper
    Hintergrund

    Description: This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50 % of Orientals have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms. , , ,

    Aliases: ALDM, ALDHI, ALDH-E2

    Molekulargewicht
    56.3 kDa
    Gen-ID
    217
    HGNC
    217
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