WHSC2 Antikörper (AA 280-511)

Produktnummer ABIN1724802

Produktdetails anti-WHSC2 Antikörper

Target: WHSC2 (Wolf-Hirschhorn Syndrome Candidate 2 (WHSC2))

Bindungsspezifität: AA 280-511

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser WHSC2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Verwendungszweck: WHSC2 Antibody

Aufreinigung: Purified antibody

Immunogen: Purified recombinant fragment of human WHSC2 (AA: 280-511) expressed in E. Coli.

Klon: 6B11H8

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-WHSC2 Antikörper (ABIN1724802)

Kerzendorfer, Hannes, Colnaghi, Abramowicz, Carpenter, Vermeesch, ODriscoll: "Characterizing the functional consequences of haploinsufficiency of NELF-A (WHSC2) and SLBP identifies novel cellular phenotypes in Wolf-Hirschhorn syndrome." in: Human molecular genetics, Vol. 21, Issue 10, pp. 2181-93, (2012) (PubMed).

Yung, Narita, Komori, Yamaguchi, Handa: "Cellular dynamics of the negative transcription elongation factor NELF." in: Experimental cell research, Vol. 315, Issue 10, pp. 1693-705, (2009) (PubMed).

Details zu WHSC2

Target: WHSC2 (Wolf-Hirschhorn Syndrome Candidate 2 (WHSC2))

Andere Bezeichnung: WHSC2 (WHSC2 Produkte)

Synonyme: BcDNA:SD07139 antikoerper, CG5874 antikoerper, Dmel\\CG5874 antikoerper, NELF antikoerper, NELF-A antikoerper, Whsc2 antikoerper, fi75f03 antikoerper, whsc2 antikoerper, wu:fi75f03 antikoerper, MGC85474 antikoerper, WHSC2 antikoerper, nelfa antikoerper, nelf-a antikoerper, p/okcl.15 antikoerper, Whsc2h antikoerper, Negative elongation factor A antikoerper, negative elongation factor complex member A antikoerper, negative elongation factor complex member A L homeolog antikoerper, negative elongation factor complex member A, Whsc2 antikoerper, Nelf-A antikoerper, Nelfa antikoerper, nelfa antikoerper, nelfa.L antikoerper, NELFA antikoerper

Hintergrund:

Description: This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93 % sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation.

Aliases: NELFA, NELF-A, P/OKcl.15

Molekulargewicht: 57.3kDa

Gen-ID: 7469

HGNC: 7469

Pathways: Chromatin Binding