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CD33 Antikörper (AA 15-237)

CD33 Reaktivität: Human FACS, ELISA, IHC Wirt: Maus Monoclonal 2C6B7 unconjugated
Produktnummer ABIN1724812
  • Target Alle CD33 Antikörper anzeigen
    CD33
    Bindungsspezifität
    • 16
    • 16
    • 13
    • 9
    • 8
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 15-237
    Reaktivität
    • 168
    • 34
    • 14
    • 13
    • 7
    • 6
    • 3
    • 1
    Human
    Wirt
    • 92
    • 81
    Maus
    Klonalität
    • 89
    • 83
    • 1
    Monoklonal
    Konjugat
    • 58
    • 16
    • 13
    • 13
    • 10
    • 5
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CD33 Antikörper ist unkonjugiert
    Applikation
    • 106
    • 100
    • 40
    • 30
    • 26
    • 26
    • 23
    • 22
    • 17
    • 14
    • 9
    • 9
    • 6
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), ELISA, Immunohistochemistry (IHC)
    Verwendungszweck
    CD33 Antibody
    Aufreinigung
    Ascitic fluid
    Immunogen
    Purified recombinant fragment of human CD33 (AA: 15-237) expressed in E. Coli.
    Klon
    2C6B7
    Isotyp
    IgG1
    Top Product
    Discover our top product CD33 Primärantikörper
  • Applikationshinweise

    ELISA: 1/10000

    FCM: 1/200 - 1/400

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Ascitic fluid containing 0.03 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Deng, Liu, Wang, Tang, Ren, Xu, Ma, Wang, Zhuang, Wang, Chen: "The prevalence of CD33 and MS4A6A variant in Chinese Han population with Alzheimer's disease." in: Human genetics, Vol. 131, Issue 7, pp. 1245-9, (2012) (PubMed).

    Schubert, Kellner, Stein, Kügler, Schwenkert, Saul, Mentz, Singer, Stockmeyer, Hillen, Mackensen, Fey: "A single-chain triplebody with specificity for CD19 and CD33 mediates effective lysis of mixed lineage leukemia cells by dual targeting." in: mAbs, Vol. 3, Issue 1, pp. 21-30, (2011) (PubMed).

  • Target
    CD33
    Andere Bezeichnung
    CD33 (CD33 Produkte)
    Synonyme
    SIGLEC-3 antikoerper, SIGLEC3 antikoerper, p67 antikoerper, Siglec-3 antikoerper, gp67 antikoerper, CD33 molecule antikoerper, CD33 antigen antikoerper, CD33 antikoerper, Cd33 antikoerper
    Hintergrund

    Description: The protein encoded by this gene belongs to putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro) and CD33 plays potential key roles in the pathogenesis of Alzheimer's disease (AD)

    Aliases: p67, SIGLEC3, SIGLEC-3

    Molekulargewicht
    39.8kDa
    Gen-ID
    945
    HGNC
    945
    UniProt
    P20138
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