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CD33 Antikörper (AA 15-237)

Name: CD33 Antikörper (AA 15-237)
Brand: antibodies-online
SKU: ABIN1724812
Price: 614.71 EUR
Availability: InStock

CD33 Reaktivität: Human FACS, WB, ELISA, IHC Wirt: Maus Monoclonal 2C6B7 unconjugated

Western blot analysis using CD33 mAb against human CD33 recombinant protein. (CD33 Antikörper (AA 15-237))

Immunohistochemical analysis of paraffin-embedded esophageal cancer tissues using CD33 mouse mAb with DAB staining. (CD33 Antikörper (AA 15-237))

IHC

Western blot analysis using CD33 mouse mAb against THP-1 (1) cell lysate. (CD33 Antikörper (AA 15-237))

Western blot analysis using CD33 mAb against HEK293 (1) and CD33 (AA: 15-237)-hIgGFc transfected HEK293 (2) cell lysate. (CD33 Antikörper (AA 15-237))

Black line: Control Antigen (100 ng), Purple line: Antigen(10 ng), Blue line: Antigen (50 ng), Red line: Antigen (100 ng), (CD33 Antikörper (AA 15-237))

ELISA

Flow cytometric analysis of HeLa cells using CD33 mouse mAb (green) and negative control (purple). (CD33 Antikörper (AA 15-237))

FACS

Immunohistochemical analysis of paraffin-embedded endometrium tissues using CD33 mouse mAb with DAB staining. (CD33 Antikörper (AA 15-237))

IHC

7 Abbildungen

(2 Referenzen)

Produktnummer ABIN1724812

Datenblatt (PDF)

Target Alle CD33 Antikörper anzeigen

CD33
Bindungsspezifität
16

16

13

9

8

5

4

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1
AA 15-237
Reaktivität
168

34

14

13

7

6

3

1
Human
Wirt
92

81
Maus
Passende Sekundärantikörper
Klonalität
89

83

1
Monoklonal
Konjugat
58

16

13

13

10

5

5

4

3

3

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
Dieser CD33 Antikörper ist unkonjugiert
Applikation
106

100

40

30

26

26

23

22

17

14

9

9

6

4

4

2

2

2

2

1

1

1

1

1

1

1
Flow Cytometry (FACS), Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Aufreinigung

purified

Immunogen

Purified recombinant fragment of human CD33 (AA: 15-237) expressed in E. coli.

Klon

2C6B7

Isotyp

IgG1

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CD33 Reaktivität: Human WB, ELISA, RNAi Wirt: Maus Monoclonal 2D12-G4 unconjugated

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CD33 Reaktivität: Human, Non-Human Primate FACS, WB, IP, IHC (fro), ICC, Func, CyTOF Wirt: Maus Monoclonal WM53 unconjugated

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CD33 Reaktivität: Human, Non-Human Primate FACS Wirt: Maus Monoclonal HIM3-4 Biotin

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CD33 Reaktivität: Human, Non-Human Primate FACS Wirt: Maus Monoclonal WM53 FITC

anti-CD33 (CD33) antibody
CD33 Reaktivität: Human, Maus, Ratte WB, IF, IHC Wirt: Kaninchen Polyclonal unconjugated

Applikationshinweise

ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, FCM: 1:200 - 1:400

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Liquid

Buffer

Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel

Sodium azide

Vorsichtsmaßnahmen

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung

4 °C/-20 °C

Informationen zur Lagerung

4°C, -20°C for long term storage
Deng, Liu, Wang, Tang, Ren, Xu, Ma, Wang, Zhuang, Wang, Chen: "The prevalence of CD33 and MS4A6A variant in Chinese Han population with Alzheimer's disease." in: Human genetics, Vol. 131, Issue 7, pp. 1245-9, (2012) (PubMed).

Schubert, Kellner, Stein, Kügler, Schwenkert, Saul, Mentz, Singer, Stockmeyer, Hillen, Mackensen, Fey: "A single-chain triplebody with specificity for CD19 and CD33 mediates effective lysis of mixed lineage leukemia cells by dual targeting." in: mAbs, Vol. 3, Issue 1, pp. 21-30, (2011) (PubMed).
Target

CD33

Andere Bezeichnung

CD33 (CD33 Produkte)

Synonyme

SIGLEC-3 antikoerper, SIGLEC3 antikoerper, p67 antikoerper, Siglec-3 antikoerper, gp67 antikoerper, CD33 molecule antikoerper, CD33 antigen antikoerper, CD33 antikoerper, Cd33 antikoerper

Hintergrund

Description: The protein encoded by this gene belongs to putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro) and CD33 plays potential key roles in the pathogenesis of Alzheimer's disease (AD)
Aliases: p67, SIGLEC3, SIGLEC-3

Molekulargewicht

39.8 kDa

Gen-ID

945

HGNC

945