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CD11b Antikörper (AA 623-728)

Name: CD11b Antikörper (AA 623-728)
Brand: antibodies-online
SKU: ABIN1724905
Price: 614.71 EUR
Availability: InStock

ITGAM Reaktivität: Human WB, ELISA, ICC Wirt: Maus Monoclonal 3A10H5 unconjugated

Western blot analysis using ITGAM mAb against human ITGAM recombinant protein. (CD11b Antikörper (AA 623-728))

Immunofluorescence analysis of Hela cells using ITGAM mouse mAb (green). (CD11b Antikörper (AA 623-728))

Western blot analysis using ITGAM mAb against HEK293 (1) and ITGAM (AA: 623-728)-hIgGFc transfected HEK293 (2) cell lysate. (CD11b Antikörper (AA 623-728))

Black line: Control Antigen (100 ng), Purple line: Antigen(10 ng), Blue line: Antigen (50 ng), Red line: Antigen (100 ng), (CD11b Antikörper (AA 623-728))

ELISA

4 Abbildungen

(2 Referenzen)

Produktnummer ABIN1724905

Datenblatt (PDF)

Target Alle CD11b (ITGAM) Antikörper anzeigen

CD11b (ITGAM) (Integrin alpha M (ITGAM))
Bindungsspezifität
16

14

10

7

6

6

5

5

3

3

3

3

3

3

3

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 623-728
Reaktivität
273

173

68

33

17

17

16

14

11

7

7

4

4

2

2

1
Human
Wirt
151

113

104

2

1

1
Maus
Passende Sekundärantikörper
Klonalität
273

96

1
Monoklonal
Konjugat
116

37

32

28

22

11

8

8

7

7

6

6

5

5

4

4

3

3

3

3

3

3

3

3

3

3

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1
Dieser CD11b Antikörper ist unkonjugiert
Applikation
276

87

82

82

58

43

37

21

20

20

13

13

12

6

5

5

5

4

3

2

2

2

2

1

1

1

1

1
Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Aufreinigung

purified

Immunogen

Purified recombinant fragment of human ITGAM (AA: 623-728) expressed in E. coli.

Klon

3A10H5

Isotyp

IgG1

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Applikationshinweise

ELISA: 1:10000, WB: 1:500 - 1:2000, ICC: 1:200 - 1:1000

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Liquid

Buffer

Purified antibody in PBS with 0.05 % sodium azide

Konservierungsmittel

Sodium azide

Vorsichtsmaßnahmen

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung

4 °C/-20 °C

Informationen zur Lagerung

4°C, -20°C for long term storage
Rhodes, Fürnrohr, Roberts, Tzircotis, Schett, Spector, Vyse: "The rs1143679 (R77H) lupus associated variant of ITGAM (CD11b) impairs complement receptor 3 mediated functions in human monocytes." in: Annals of the rheumatic diseases, Vol. 71, Issue 12, pp. 2028-34, (2012) (PubMed).

Grüger, Reiners, Schnitzler, Brandenburg, Zündorf: "Garenoxacin-induced increase of CD11b expression on human polymorphonuclear neutrophils does not affect phagocytosis and killing of Staphylococcus aureus." in: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, Vol. 17, Issue 2, pp. 291-6, (2011) (PubMed).
Target

CD11b (ITGAM) (Integrin alpha M (ITGAM))

Andere Bezeichnung

ITGAM (ITGAM Produkte)

Synonyme

CD11b/CD18 antikoerper, CR3 antikoerper, CR3A antikoerper, Cd11b antikoerper, F730045J24Rik antikoerper, Ly-40 antikoerper, MAC1 antikoerper, Mac-1 antikoerper, Mac-1a antikoerper, CD11B antikoerper, MAC-1 antikoerper, MAC1A antikoerper, MO1A antikoerper, SLEB6 antikoerper, C3bi antikoerper, integrin subunit alpha M antikoerper, integrin alpha M antikoerper, integrin, alpha M (complement component 3 receptor 3 subunit) antikoerper, integrin alpha-M antikoerper, ITGAM antikoerper, Itgam antikoerper, LOC100351865 antikoerper

Hintergrund

Description: This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. ,
Aliases: CR3A, MO1A, CD11B, MAC-1, MAC1A, SLEB6

Molekulargewicht

127.1 kDa

Gen-ID

3684

HGNC

3684

Pathways

Apoptose, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation