MME Antikörper (AA 52-246)

Produktnummer ABIN1724916

Produktdetails anti-MME Antikörper

Target: MME (Membrane Metallo-Endopeptidase (MME))

Bindungsspezifität: AA 52-246

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MME Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA

Verwendungszweck: CD10 Antibody

Aufreinigung: Purified antibody

Immunogen: Purified recombinant fragment of human CD10 (AA: 52-246) expressed in E. Coli.

Klon: 5E9A5

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA: 1/10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-MME Antikörper (ABIN1724916)

Thomas-Pfaab, Annereau, Munsch, Guilbaud, Garrido, Paul, Brousset, Lamant, Meyer: "CD10 expression by melanoma cells is associated with aggressive behavior in vitro and predicts rapid metastatic progression in humans." in: Journal of dermatological science, Vol. 69, Issue 2, pp. 105-13, (2013) (PubMed).

Details zu MME

Target: MME (Membrane Metallo-Endopeptidase (MME))

Andere Bezeichnung: CD10 (MME Produkte)

Hintergrund:

Description: This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85 % of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing.

Aliases: MME, NEP, SFE, CALLA

Molekulargewicht: 85.5kDa

Gen-ID: 4311

HGNC: 4311

UniProt: P08473

Pathways: RTK Signalweg, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Smooth Muscle Cell Migration