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MFN2 Antikörper (AA 370-600)

MFN2 Reaktivität: Human WB, IHC, ICC, IF Wirt: Maus Monoclonal S153-5 unconjugated
Produktnummer ABIN1741233
  • Target Alle MFN2 Antikörper anzeigen
    MFN2 (Mitofusin 2 (MFN2))
    Bindungsspezifität
    • 20
    • 7
    • 6
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 370-600
    Reaktivität
    • 65
    • 29
    • 28
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 53
    • 23
    • 2
    Maus
    Klonalität
    • 55
    • 23
    Monoklonal
    Konjugat
    • 34
    • 6
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser MFN2 Antikörper ist unkonjugiert
    Applikation
    • 61
    • 45
    • 32
    • 13
    • 12
    • 8
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)
    Spezifität
    Detects ~90 kDa. No cross-reactivity against Mitofusin-1.
    Kreuzreaktivität
    Human, Maus, Ratte
    Aufreinigung
    Protein G Purified
    Immunogen
    Fusion protein amino acids 370-600 (cytoplasmic N-terminus) of mouse Mitofusin-2. Rat: 97% identity (226/231 amino acids identical). Human: 92% identity (214/231 amino acids identical) ~55% identity with Mitofusin-1.
    Klon
    S153-5
    Isotyp
    IgG2a
    Top Product
    Discover our top product MFN2 Primärantikörper
  • Applikationshinweise
    • WB (1:1000)
    • ICC/IF (1:100)
    • optimal dilutions for assays should be determined by the user.
    Kommentare

    1 μg/ml of ABIN1741233 was sufficient for detection of Mitofusin-2 in 20 μg of mouse cardiac mitochondrial lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS pH 7.4, 50 % glycerol, 0.1 % sodium azide, Storage buffer may change when conjugated
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    -20°C
  • Target
    MFN2 (Mitofusin 2 (MFN2))
    Andere Bezeichnung
    Mitofusin 2 (MFN2 Produkte)
    Synonyme
    CG3869 antikoerper, Dmel\\CG3869 antikoerper, MARF antikoerper, Marf-1 antikoerper, Mfn antikoerper, anon-WO0125274.3 antikoerper, dMFN antikoerper, dMfn antikoerper, dmfn antikoerper, marf antikoerper, mfn antikoerper, mfn2 antikoerper, MFN2 antikoerper, hsg antikoerper, cmt2a antikoerper, cprp1 antikoerper, cmt2a2 antikoerper, CMT2A antikoerper, CMT2A2 antikoerper, CPRP1 antikoerper, HSG antikoerper, D630023P19Rik antikoerper, Fzo antikoerper, mg:cb01g09 antikoerper, si:dkeyp-104h9.2 antikoerper, wu:fb79a11 antikoerper, mitofusin 2 antikoerper, Mitochondrial assembly regulatory factor antikoerper, mitofusin-2 antikoerper, mitofusin 2 L homeolog antikoerper, MFN2 antikoerper, Marf antikoerper, mfn2 antikoerper, LOC100186475 antikoerper, Mfn2 antikoerper, mfn2.L antikoerper
    Hintergrund
    Mitofusin-2 (Mfn2) is a membrane protein of the mitochondria and is important in mitochondrial fusion in mammalian cells. Mfn2 activity has also been implicated in mitochondrial metabolism and the loss of Mfn2 may be the reason for certain metabolic modifications that are seen in individuals with obesity. Mfn2 has been associated with maintaining the membrane potential of the mitochondria. Mfn2 has been shown to hinder mitochondrial antiviral signaling by inhibiting production of type 1 interferons. Mfn2 is a p53-inducible target and involved in cell proliferation, apoptosis promotion and tumor suppression.
    Gen-ID
    170731
    NCBI Accession
    NP_573464
    UniProt
    Q80U63
    Pathways
    Skeletal Muscle Fiber Development
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