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SHANK3 Antikörper (AA 538-626)

SHANK3 Reaktivität: Ratte WB, IHC, IF, ICC Wirt: Maus Monoclonal S367-51 unconjugated
Produktnummer ABIN1741251
  • Target Alle SHANK3 Antikörper anzeigen
    SHANK3 (SH3 and Multiple Ankyrin Repeat Domains 3 (SHANK3))
    Bindungsspezifität
    • 15
    • 10
    • 9
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 538-626
    Reaktivität
    • 43
    • 11
    • 10
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Ratte
    Wirt
    • 26
    • 21
    Maus
    Klonalität
    • 26
    • 21
    Monoklonal
    Konjugat
    • 13
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SHANK3 Antikörper ist unkonjugiert
    Applikation
    • 31
    • 27
    • 22
    • 21
    • 17
    • 13
    • 13
    • 10
    • 8
    • 5
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    Detects ~190 kDa. Cross-reacts with SHANK1. Does not cross-react with SHANK2.
    Kreuzreaktivität
    Human, Maus, Ratte
    Aufreinigung
    Protein G Purified
    Immunogen
    Fusion protein amino acids 538-626 (SH3 domain) of rat SHANK3. Mouse: 100% identity (89/89 amino acids identical). Human: 97% identity (87/89 amino acids identical). ~70% identity with SHANK1 and SHANK2.
    Klon
    S367-51
    Isotyp
    IgG2a
    Top Product
    Discover our top product SHANK3 Primärantikörper
  • Applikationshinweise
    • WB (1:1000)
    • ICC/IF (1:100)
    • optimal dilutions for assays should be determined by the user.
    Kommentare

    1 μg/ml of ABIN1741251 was sufficient for detection of SHANK1/SHANK3 in 20 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS pH 7.4, 50 % glycerol, 0.1 % sodium azide, Storage buffer may change when conjugated
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    -20°C
  • Target
    SHANK3 (SH3 and Multiple Ankyrin Repeat Domains 3 (SHANK3))
    Andere Bezeichnung
    SHANK3 (SHANK3 Produkte)
    Synonyme
    DEL22q13.3 antikoerper, PROSAP2 antikoerper, PSAP2 antikoerper, SCZD15 antikoerper, SPANK-2 antikoerper, Prosap2 antikoerper, AI841104 antikoerper, Shank3b antikoerper, SH3 and multiple ankyrin repeat domains 3 antikoerper, SH3 and multiple ankyrin repeat domains protein 3 antikoerper, SHANK3 antikoerper, shank3 antikoerper, Shank3 antikoerper
    Hintergrund
    SHANK proteins are scaffolding adaptors that have been shown to integrate neurotransmitter receptors into the cortical cytoskeleton at postsynaptic densities. SHANK1-3 of the SHANK/ProSAP family are molecular scaffolds in the postsynaptic density (PSD). SHANK recruits betaPIX and PAK to dendritic spines to regulate postsynaptic structure and interacts with ionotropic receptor and metabotropic glutamate receptor complexes. Transcript splice variation in the Shank family influences the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain to ensure normal development.
    Gen-ID
    59312
    UniProt
    Q9JLU4
    Pathways
    Synaptic Membrane, Tube Formation, Regulation of long-term Neuronal Synaptic Plasticity
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