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p53 Antikörper

TP53 Reaktivität: Human WB, ELISA, IHC, FACS, IHC (p), IHC (fro) Wirt: Maus Monoclonal Pab122 unconjugated

Produktnummer ABIN1838032

Datenblatt (PDF)

Target Alle p53 (TP53) Antikörper anzeigen

p53 (TP53) (Tumor Protein P53 (TP53))
Reaktivität
835

255

211

107

50

34

33

19

10

9

7

6

6

3

3

3

3

2

2

2

2

1

1

1
Human
Wirt
623

229

6

2

1
Maus
Passende Sekundärantikörper
Klonalität
559

301

1
Monoklonal
Konjugat
485

38

32

19

19

13

13

13

13

13

13

13

13

13

12

12

11

11

11

11

11

11

11

5

5

5

5

5

5

2

2

2

2

2

2

2

1

1

1

1

1

1
Dieser p53 Antikörper ist unkonjugiert
Applikation
668

298

250

202

200

149

128

124

119

68

59

35

18

16

13

12

9

9

8

6

4

3

3

3

3

2

2

2

1

1

1

1

1
Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Spezifität

The p53 gene is located on human chromosome 17p13.1. Mutation and/or allelic loss of this gene is one of the causes of the occurrence of a variety of mesenchymal and epithelial tumors. If it occurs in the germ line, such tumors run in families. P53 binds to a DNA consensus sequence, the p53 response element, and it regulates normal cell growth cycle events by activating transcription of genes, involved either in progression through the cycle, or causing arrest in G1 when the genome is damaged. In most transformed and tumor cells the concentration of p53 is increased 5-1000 fold over the minute concentrations (1000 Molecules cell) in normal cells, principally due to the increased half-life (4 h) compared to that of the wild-type (20 min). P53 localizes in the nucleus, but is detectable at the plasma membrane during mitosis and when certain mutations modulate cytoplasmic/nuclear distribution.

Aufreinigung

Purified

Immunogen

Recombinant human p53 protein. Splenocytes were fused with mouse myeloma P3-X63/AG8.653 cells.

Type of Immunogen: Recombinant protein

Klon

Pab122

Isotyp

IgG1 kappa

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anti-Tumor Protein P53 (TP53) (N-Term) antibody
TP53 Reaktivität: Human WB, IF, IHC (p), IP, ICC Wirt: Kaninchen Polyclonal unconjugated

anti-Tumor Protein P53 (TP53) antibody
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anti-Tumor Protein P53 (TP53) (pSer392) antibody
TP53 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated

anti-Tumor Protein P53 (TP53) (AA 1-100) antibody
TP53 Reaktivität: Human WB, IHC, IP Wirt: Kaninchen Polyclonal unconjugated

anti-Tumor Protein P53 (TP53) (AA 301-393) antibody
TP53 Reaktivität: Human, Maus, Ratte, Ziege WB, ELISA, FACS, IHC (p), ICC, IF (cc), IF (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated

anti-Tumor Protein P53 (TP53) (AA 293-322) antibody
TP53 Reaktivität: Human WB, IF, IHC (p) Wirt: Kaninchen Polyclonal RB7777 unconjugated

anti-Tumor Protein P53 (TP53) (pSer33) antibody
TP53 Reaktivität: Human, Maus, Ratte WB, IHC Wirt: Kaninchen Polyclonal unconjugated

anti-Tumor Protein P53 (TP53) (AA 94-201) antibody
TP53 Reaktivität: Human WB, ELISA, IF, IHC (p), IP Wirt: Maus Monoclonal 2C3 unconjugated

anti-Tumor Protein P53 (TP53) (AA 94-201) antibody
TP53 Reaktivität: Human WB, ELISA, IHC (p), PLA, RNAi Wirt: Maus Monoclonal 2C11 unconjugated

anti-Tumor Protein P53 (TP53) (acLys319) antibody
TP53 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated

Applikationshinweise

Optimal working dilution should be determined by the investigator.

Kommentare

Target Species of Antibody: Human

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Liquid

Konzentration

Lot specific

Buffer

PBS, 0.05 % sodium azide

Konservierungsmittel

Sodium azide

Vorsichtsmaßnahmen

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung

4 °C

Informationen zur Lagerung

Store at 4°C.
Target

p53 (TP53) (Tumor Protein P53 (TP53))

Andere Bezeichnung

TP53 / p53 (TP53 Produkte)

Hintergrund

Name/Gene ID: TP53
Family: P53

Synonyms: TP53, BCC7, Cellular tumor antigen p53, p53, TRP53, p53 tumor suppressor, Phosphoprotein p53, Antigen NY-CO-13, Tumor protein p53, Tumor suppressor p53, LFS1

Gen-ID

7157

UniProt

P04637

Pathways

p53 Signalweg, MAPK Signalweg, PI3K-Akt Signalweg, Apoptose, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagie, Warburg Effekt