C17orf53 Antikörper (AA 282-527)

Produktnummer ABIN1842990

Produktdetails anti-C17orf53 Antikörper

Target: C17orf53 (C17ORF53) (Chromosome 17 Open Reading Frame 53 (C17ORF53))

Bindungsspezifität: AA 282-527

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser C17orf53 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (fixed cells) (IF/ICC)

Aufreinigung: Purified antibody

Immunogen: Purified recombinant fragment of human C17ORF53 (AA: 282-527) expressed in E. coli.

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.0 mg/mL

Buffer: PBS with 0.05 % sodium azide and 0.5 % protein stabilizer.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.

Details zu C17orf53

Target: C17orf53 (C17ORF53) (Chromosome 17 Open Reading Frame 53 (C17ORF53))

Andere Bezeichnung: C17ORF53 (C17ORF53 Produkte)

Synonyme: chromosome 17 open reading frame 53 antikoerper, C17orf53 antikoerper

Hintergrund: C17orf53 (chromosome 17 open reading frame 53) is a 647 amino acid protein that is encoded by a gene mapping to human chromosome 17.Chromosome 17 makes up over 2.5% of the human genome with about 81 million bases encoding over 1,200 genes.Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1.Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death.Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome.Like p53, BRCA1 is directly involved in DNA repair, specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell growth.Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17.

Molekulargewicht: 69.8 kDa

Gen-ID: 78995

UniProt: Q8N3J3