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C17orf53 Antikörper (AA 282-527)

C17ORF53 Reaktivität: Human WB, ELISA, FACS, IF/ICC Wirt: Maus Monoclonal unconjugated
Produktnummer ABIN1842990
  • Target Alle C17orf53 (C17ORF53) Produkte
    C17orf53 (C17ORF53) (Chromosome 17 Open Reading Frame 53 (C17ORF53))
    Bindungsspezifität
    • 5
    • 1
    • 1
    • 1
    • 1
    AA 282-527
    Reaktivität
    • 31
    • 15
    • 15
    • 3
    • 2
    • 2
    • 2
    • 1
    Human
    Wirt
    • 19
    • 12
    Maus
    Klonalität
    • 19
    • 12
    Monoklonal
    Konjugat
    • 10
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser C17orf53 Antikörper ist unkonjugiert
    Applikation
    • 24
    • 13
    • 5
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (fixed cells) (IF/ICC)
    Aufreinigung
    Purified antibody
    Immunogen
    Purified recombinant fragment of human C17ORF53 (AA: 282-527) expressed in E. coli.
    Isotyp
    IgG2b
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1.0 mg/mL
    Buffer
    PBS with 0.05 % sodium azide and 0.5 % protein stabilizer.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
  • Target
    C17orf53 (C17ORF53) (Chromosome 17 Open Reading Frame 53 (C17ORF53))
    Andere Bezeichnung
    C17ORF53 (C17ORF53 Produkte)
    Synonyme
    chromosome 17 open reading frame 53 antikoerper, C17orf53 antikoerper
    Hintergrund
    C17orf53 (chromosome 17 open reading frame 53) is a 647 amino acid protein that is encoded by a gene mapping to human chromosome 17.Chromosome 17 makes up over 2.5% of the human genome with about 81 million bases encoding over 1,200 genes.Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1.Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death.Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome.Like p53, BRCA1 is directly involved in DNA repair, specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell growth.Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17.
    Molekulargewicht
    69.8 kDa
    Gen-ID
    78995
    UniProt
    Q8N3J3
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