WHSC2 Antikörper (AA 280-511)

Produktnummer ABIN1846367

Produktdetails anti-WHSC2 Antikörper

Target: WHSC2 (Wolf-Hirschhorn Syndrome Candidate 2 (WHSC2))

Bindungsspezifität: AA 280-511

Reaktivität: Human, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser WHSC2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (fixed cells) (IF/ICC)

Aufreinigung: Purified antibody

Immunogen: Purified recombinant fragment of human WHSC2 (AA: 280-511) expressed in E. coli.

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.0 mg/mL

Buffer: PBS with 0.05 % sodium azide and 0.5 % protein stabilizer.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.

Details zu WHSC2

Target: WHSC2 (Wolf-Hirschhorn Syndrome Candidate 2 (WHSC2))

Andere Bezeichnung: WHSC2 (WHSC2 Produkte)

Hintergrund: This gene is expressed ubiquitously with higher levels in fetal than in adult tissues.It encodes a protein sharing 93% sequence identity with the mouse protein.Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4.This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome.The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients.This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation.

Molekulargewicht: 57.3 kDa

Gen-ID: 7469

Pathways: Chromatin Binding