IFT74 Antikörper (C-Term)

Produktnummer ABIN185213

Produktdetails anti-IFT74 Antikörper

Target: IFT74 (Intraflagellar Transport Protein 74 Homolog (IFT74))

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser IFT74 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB)

Verwendungszweck: CMG1 / CCDC2 / IFT74

Sequenz: KTIVDALHST SGN

Kreuzreaktivität: Human, Ratte

Aufreinigung: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

Güteklasse: Verified

Immunogen: Peptide with sequence C-KTIVDALHSTSGN, from the C Terminus of the protein sequence according to NP_001092692.1, NP_001092693.1, NP_079379.2, AAK77221.1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Western Blot: Approx 70 kDa band observed in lysates of cell line HEK293 (calculated MW of 69.2 kDa according to AAK77221.1). The observed molecular weight corresponds to earlier findings in literature (Momeni et al, BMC Neurol. 2006 Dec 13,6:44., PMID: 17

Peptide ELISA: antibody detection limit dilution 1:32000.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Supplied at 0.5 mg/mL in Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Minimize freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot and store at -20°C, with minimal freeze/thawing. A working aliquot may be refrigerated at 4°C for a few weeks and still remain viable.

Referenzen für anti-IFT74 Antikörper (ABIN185213)

Boldt, Mans, Won, van Reeuwijk, Vogt, Kinkl, Letteboer, Hicks, Hurd, Naggert, Texier, den Hollander, Koenekoop, Bennett, Cremers, Gloeckner, Nishina, Roepman, Ueffing: "Disruption of intraflagellar protein transport in photoreceptor cilia causes Leber congenital amaurosis in humans and mice." in: The Journal of clinical investigation, Vol. 121, Issue 6, pp. 2169-80, (2011) (PubMed).

Momeni, Schymick, Jain, Cookson, Cairns, Greggio, Greenway, Berger, Pickering-Brown, Chiò, Fung, Holtzman, Huey, Wassermann, Adamson, Hutton, Rogaeva, St George-Hyslop, Rothstein, Hardiman, Grafman et al.: "Analysis of IFT74 as a candidate gene for chromosome 9p-linked ALS-FTD. ..." in: BMC neurology, Vol. 6, pp. 44, (2007) (PubMed).

Details zu IFT74

Target: IFT74 (Intraflagellar Transport Protein 74 Homolog (IFT74))

Andere Bezeichnung: IFT74 (IFT74 Produkte)

Synonyme: CCDC2 antikoerper, DKFZp469F1522 antikoerper, 1700029H06Rik antikoerper, Ccdc2 antikoerper, Cmg1 antikoerper, b2b796Clo antikoerper, CMG-1 antikoerper, CMG1 antikoerper, intraflagellar transport protein 74/72 antikoerper, intraflagellar transport 74 antikoerper, intraflagellar transport protein 74 homolog antikoerper, IFT74 antikoerper, ift74 antikoerper, LOC100632007 antikoerper, LOC100649180 antikoerper, Ift74 antikoerper

Hintergrund: IFT74, CCDC2, CMG-1, FLJ22621, MGC111562, intraflagellar transport 74 homolog (Chlamydomonas), capillary morphogenesis protein 1, coiled-coil domain containing 2, CMG1

Gen-ID: 80173, 313365

NCBI Accession: NP_001092692, NP_001092693, NP_079379

Pathways: Hedgehog Signalweg, Chromatin Binding