Caspase 3 Antikörper (N-Term)
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- Target Alle Caspase 3 (CASP3) Antikörper anzeigen
- Caspase 3 (CASP3)
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Bindungsspezifität
- N-Term
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser Caspase 3 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Spezifität
- Species Reactivity: Human, others not tested.
- Sterilität
- 0.2 μm filtered
- Immunogen
- Hybridoma produced by the fusion of splenocytes from mice immunized with recombinant human Caspase-3 protein and mouse myeloma cells.
- Klon
- AM1-4
- Isotyp
- IgG1
- Top Product
- Discover our top product CASP3 Primärantikörper
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anti-Caspase 3 (CASP3) (AA 60-100) antibody
CASP3 Reaktivität: Human, Maus, Ratte, Rind (Kuh), Ziege WB, IF (cc) Wirt: Kaninchen Polyclonal unconjugated
anti-Caspase 3 (CASP3) (AA 67-175) antibodyCASP3 Reaktivität: Human, Maus, Ratte WB, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
anti-Caspase 3 (CASP3) (AA 220-236), (C-Term) antibodyCASP3 Reaktivität: Human WB, IHC (p), ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Caspase 3 (CASP3) antibodyCASP3 Reaktivität: Human, Maus, Ratte WB, IHC Wirt: Maus Monoclonal 5E1 unconjugated
anti-Caspase 3 (CASP3) (pSer150) antibodyCASP3 Reaktivität: Human, Maus, Ratte WB, IHC, ELISA, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Caspase 3 (CASP3) (Internal Region) antibodyCASP3 Reaktivität: Human, Maus, Ratte, Rind (Kuh) WB, IHC, ELISA, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Caspase 3 (CASP3) (AA 100-200) antibodyCASP3 Reaktivität: Human WB, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
anti-Caspase 3 (CASP3) (cleaved) antibodyCASP3 Reaktivität: Human, Maus, Ratte IHC, IF Wirt: Kaninchen Polyclonal unconjugated
anti-Caspase 3 (CASP3) (AA 29-175) antibodyCASP3 Reaktivität: Human WB, IHC, IP, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Caspase 3 (CASP3) (AA 29-175) antibodyCASP3 Reaktivität: Human WB, IHC, IP, ICC Wirt: Maus Monoclonal C3 unconjugated
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- Applikationshinweise
- Western Blot The optimal dilution for a specific application should be determined by the researcher.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- Mouse monoclonal antibody against human Caspase-3 (cysteine-requiring aspartate protease-3). Available in 100 ul vials at a concentration of 1 mg/ml (100ug) in PBS with 0.08% sodium azide. Purified and 0.2 µm sterile filtered.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C
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- Target
- Caspase 3 (CASP3)
- Andere Bezeichnung
- Caspase-3 (CASP3 Produkte)
- Hintergrund
- Caspase-3 along with caspase 7 and 6 form a group of effector caspases that are responsible for the cleavage of multiple substrates including the cytyokeratins, PARP, alpha fodrin, NuMA and others. Caspase-7 occurs in three variant forms. Caspase-3-like activities are required for Fas-mediated apoptosis. However, the role of caspase-1 and caspase-3 in mediating Fas-induced cell death is not clear. Although wild-type, caspase-1(-/-), and caspase-3(-/-) hepatocytes were killed at a similar rate when co-cultured with FasL expressing NIH 3T3 cells, caspase-3(-/-) hepatocytes displayed drastically different morphological changes as well as significantly delayed DNA fragmentation observed in hepatocytes. Cleavage of various caspase substrates implicates apoptotic events, including gesolin, fodin, lamin B, and DFF45/ICAD are delayed or absent. The altered cleavage of these key substrates is likely responsible for the aberrant apoptosis observed in both hepatocytes and thymocytes deficient in caspase-3.
- Pathways
- Apoptose, Caspase Kaskade in der Apoptose, Sensory Perception of Sound, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Activated T Cell Proliferation
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