CD46 Antikörper (AA 330-361)
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- Target Alle CD46 Antikörper anzeigen
- CD46
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Bindungsspezifität
- AA 330-361
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser CD46 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Aufreinigung
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- Immunogen
- This CD46 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 330-361 amino acids from the Central region of human CD46.
- Isotyp
- Ig Fraction
- Top Product
- Discover our top product CD46 Primärantikörper
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- Applikationshinweise
- WB: 1:1000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Haltbarkeit
- 6 months
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Characterization of human membrane cofactor protein (MCP; CD46) on spermatozoa." in: Molecular reproduction and development, Vol. 62, Issue 4, pp. 534-46, (2002) (PubMed).
: "Characterization of a cDNA clone coding for human testis membrane cofactor protein (MCP, CD46)." in: Molecular reproduction and development, Vol. 34, Issue 1, pp. 107-13, (1993) (PubMed).
: "Membrane cofactor protein of the complement system: alternative splicing of serine/threonine/proline-rich exons and cytoplasmic tails produces multiple isoforms that correlate with protein phenotype." in: The Journal of experimental medicine, Vol. 174, Issue 1, pp. 93-102, (1991) (PubMed).
: "Alternatively spliced RNAs encode several isoforms of CD46 (MCP), a regulator of complement activation." in: Immunogenetics, Vol. 33, Issue 5-6, pp. 335-44, (1991) (PubMed).
: "Molecular cloning and chromosomal localization of human membrane cofactor protein (MCP). Evidence for inclusion in the multigene family of complement-regulatory proteins." in: The Journal of experimental medicine, Vol. 168, Issue 1, pp. 181-94, (1988) (PubMed).
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Characterization of human membrane cofactor protein (MCP; CD46) on spermatozoa." in: Molecular reproduction and development, Vol. 62, Issue 4, pp. 534-46, (2002) (PubMed).
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- Target
- CD46
- Andere Bezeichnung
- CD46 (CD46 Produkte)
- Synonyme
- AHUS2 antikoerper, MCP antikoerper, MIC10 antikoerper, TLX antikoerper, TRA2.10 antikoerper, Mcp antikoerper, CD46 antikoerper, CD46 molecule antikoerper, CD46 antigen, complement regulatory protein antikoerper, CD46 molecule, complement regulatory protein antikoerper, membrane cofactor protein-like antikoerper, CD46 antikoerper, Cd46 antikoerper, LOC100341359 antikoerper, LOC103789310 antikoerper
- Hintergrund
- Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.
- Molekulargewicht
- 43747
- NCBI Accession
- NP_002380, NP_722548, NP_758860, NP_758861, NP_758862, NP_758863, NP_758869, NP_758871
- UniProt
- P15529
- Pathways
- Regulation of Actin Filament Polymerization
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