CDKN3 Antikörper (N-Term)
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- Target Alle CDKN3 Antikörper anzeigen
- CDKN3 (Cyclin-Dependent Kinase Inhibitor 3 (CDKN3))
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Bindungsspezifität
- AA 39-68, N-Term
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser CDKN3 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Aufreinigung
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- Immunogen
- This CDKN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-68 amino acids from the N-terminal region of human CDKN3.
- Klon
- RB42328
- Isotyp
- Ig Fraction
- Top Product
- Discover our top product CDKN3 Primärantikörper
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- Applikationshinweise
- WB: 1:1000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Haltbarkeit
- 6 months
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High expression levels of IKKalpha and IKKbeta are necessary for the malignant properties of liver cancer." in: International journal of cancer. Journal international du cancer, Vol. 126, Issue 5, pp. 1263-74, (2010) (PubMed).
: "An approach based on a genome-wide association study reveals candidate loci for narcolepsy." in: Human genetics, Vol. 128, Issue 4, pp. 433-41, (2010) (PubMed).
: "KAP1 dictates p53 response induced by chemotherapeutic agents via Mdm2 interaction." in: Biochemical and biophysical research communications, Vol. 351, Issue 1, pp. 216-22, (2006) (PubMed).
: "Transcriptional repression activity of PAX3 is modulated by competition between corepressor KAP1 and heterochromatin protein 1." in: Biochemical and biophysical research communications, Vol. 349, Issue 2, pp. 573-81, (2006) (PubMed).
: "Binding of HTm4 to cyclin-dependent kinase (Cdk)-associated phosphatase (KAP).Cdk2.cyclin A complex enhances the phosphatase activity of KAP, dissociates cyclin A, and facilitates KAP..." in: The Journal of biological chemistry, Vol. 280, Issue 17, pp. 17235-42, (2005) (PubMed).
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High expression levels of IKKalpha and IKKbeta are necessary for the malignant properties of liver cancer." in: International journal of cancer. Journal international du cancer, Vol. 126, Issue 5, pp. 1263-74, (2010) (PubMed).
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- Target
- CDKN3 (Cyclin-Dependent Kinase Inhibitor 3 (CDKN3))
- Andere Bezeichnung
- CDKN3 (CDKN3 Produkte)
- Hintergrund
- The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
- Molekulargewicht
- 23805
- NCBI Accession
- NP_001124323, NP_005183
- UniProt
- Q16667
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