This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This CHRNB4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 422-450 amino acids from the C-terminal region of human CHRNB4.
CHRNB4
Reaktivität: Human
WB, ELISA
Wirt: Kaninchen
Polyclonal
FITC
Applikationshinweise
WB: 1:1000
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Buffer
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C,-20 °C
Haltbarkeit
6 months
Zhang, Kranzler, Poling, Gelernter: "Variation in the nicotinic acetylcholine receptor gene cluster CHRNA5-CHRNA3-CHRNB4 and its interaction with recent tobacco use influence cognitive flexibility." in: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, Vol. 35, Issue 11, pp. 2211-24, (2010) (PubMed).
Amos, Gorlov, Dong, Wu, Zhang, Lu, Scheet, Greisinger, Mills, Spitz: "Nicotinic acetylcholine receptor region on chromosome 15q25 and lung cancer risk among African Americans: a case-control study." in: Journal of the National Cancer Institute, Vol. 102, Issue 15, pp. 1199-205, (2010) (PubMed).
Saccone, Schwantes-An, Wang, Grucza, Breslau, Hatsukami, Johnson, Rice, Goate, Bierut: "Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans." in: Genes, brain, and behavior, Vol. 9, Issue 7, pp. 741-50, (2010) (PubMed).
Hansen, Xiao, Rice, Bracci, Wrensch, Sison, Chang, Smirnov, Patoka, Seldin, Quesenberry, Kelsey, Wiencke: "Fine mapping of chromosome 15q25.1 lung cancer susceptibility in African-Americans." in: Human molecular genetics, Vol. 19, Issue 18, pp. 3652-61, (2010) (PubMed).
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.