CTNS Antikörper (C-Term)

Produktnummer ABIN1881240

Produktdetails anti-CTNS Antikörper

Target: CTNS (Cystinosis, Nephropathic (CTNS))

Bindungsspezifität: AA 341-367, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CTNS Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CTNS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 341-367 amino acids from the C-terminal region of human CTNS.

Klon: RB40519

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-CTNS Antikörper (ABIN1881240)

Taranta, Wilmer, van den Heuvel, Bencivenga, Bellomo, Levtchenko, Emma: "Analysis of CTNS gene transcripts in nephropathic cystinosis." in: Pediatric nephrology (Berlin, Germany), Vol. 25, Issue 7, pp. 1263-7, (2010) (PubMed).

Kumar, Bachhawat: "A futile cycle, formed between two ATP-dependant gamma-glutamyl cycle enzymes, gamma-glutamyl cysteine synthetase and 5-oxoprolinase: the cause of cellular ATP depletion in nephrotic cystinosis?" in: Journal of biosciences, Vol. 35, Issue 1, pp. 21-5, (2010) (PubMed).

Bellomo, Corallini, Pastore, Palma, Laurenzi, Emma, Taranta: "Modulation of CTNS gene expression by intracellular thiols." in: Free radical biology & medicine, Vol. 48, Issue 7, pp. 865-72, (2010) (PubMed).

Aldahmesh, Humeidan, Almojalli, Khan, Rajab, AL-Abbad, Meyer, Alkuraya: "Characterization of CTNS mutations in Arab patients with cystinosis." in: Ophthalmic genetics, Vol. 30, Issue 4, pp. 185-9, (2009) (PubMed).

Macías-Vidal, Rodés, Hernández-Pérez, Vilaseca, Coll: "Analysis of the CTNS gene in 32 cystinosis patients from Spain." in: Clinical genetics, Vol. 76, Issue 5, pp. 486-9, (2009) (PubMed).

Details zu CTNS

Target: CTNS (Cystinosis, Nephropathic (CTNS))

Andere Bezeichnung: CTNS (CTNS Produkte)

Synonyme: CTNS-LSB antikoerper, PQLC4 antikoerper, AI195360 antikoerper, AW049661 antikoerper, zgc:110194 antikoerper, CTNS antikoerper, cystinosin, lysosomal cystine transporter antikoerper, cystinosis, nephropathic antikoerper, cystinosin, lysosomal cystine transporter L homeolog antikoerper, CTNS antikoerper, Ctns antikoerper, ctns antikoerper, ctns.L antikoerper

Hintergrund: This gene encodes a seven-transmembrane domain protein that functions to transport cystine out of lysosomes. Its activity is driven by the H+ electrochemical gradient of the lysosomal membrane. Mutations in this gene cause cystinosis, a lysosomal storage disorder. Alternative splicing results in multiple transcript variants.

Molekulargewicht: 41738

NCBI Accession: NP_001026851, NP_004928

UniProt: O60931