p300 Antikörper (pSer1834)

Produktnummer ABIN1881299

Produktdetails anti-p300 Antikörper

Target: p300 (EP300) (E1A Binding Protein P300 (EP300))

Bindungsspezifität: pSer1834

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser p300 Antikörper ist unkonjugiert

Applikation: Dot Blot (DB)

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This EP300 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1834 of human EP300.

Klon: RB41431

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: DB: 1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-p300 Antikörper (ABIN1881299)

Zhang, Zhang, Rui, Liu: "p300-mediated acetylation stabilizes the Th-inducing POK factor." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 7, pp. 3960-9, (2010) (PubMed).

Vempati, Jayani, Notani, Sengupta, Galande, Haldar: "p300-mediated acetylation of histone H3 lysine 56 functions in DNA damage response in mammals." in: The Journal of biological chemistry, Vol. 285, Issue 37, pp. 28553-64, (2010) (PubMed).

Reynoird, Schwartz, Delvecchio, Sadoul, Meyers, Mukherjee, Caron, Kimura, Rousseaux, Cole, Panne, French, Khochbin: "Oncogenesis by sequestration of CBP/p300 in transcriptionally inactive hyperacetylated chromatin domains." in: The EMBO journal, Vol. 29, Issue 17, pp. 2943-52, (2010) (PubMed).

Jang, Choi, Jeong, Lee: "Phosphorylation of p300 by ATM controls the stability of NBS1." in: Biochemical and biophysical research communications, Vol. 397, Issue 4, pp. 637-43, (2010) (PubMed).

Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, (2010) (PubMed).

Details zu p300

Target: p300 (EP300) (E1A Binding Protein P300 (EP300))

Andere Bezeichnung: EP300 (EP300 Produkte)

Synonyme: KAT3B antikoerper, RSTS2 antikoerper, p300 antikoerper, A430090G16 antikoerper, A730011L11 antikoerper, p300 HAT antikoerper, E1A binding protein p300 antikoerper, histone acetyltransferase p300 antikoerper, EP300 antikoerper, LOC446056 antikoerper, ep300 antikoerper, Ep300 antikoerper

Hintergrund: This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.

Molekulargewicht: 264161

NCBI Accession: NP_001420

UniProt: Q09472

Pathways: p53 Signalweg, Notch Signalweg, Interferon-gamma Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Lipid Metabolism by PPARalpha, Regulation of Muscle Cell Differentiation, Regulation of Cell Size