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FADD Antikörper (AA 106-135)

FADD Reaktivität: Human WB Wirt: Kaninchen Polyclonal RB40884 unconjugated
Produktnummer ABIN1881331
  • Target Alle FADD Antikörper anzeigen
    FADD (Fas (TNFRSF6)-Associated Via Death Domain (FADD))
    Bindungsspezifität
    • 17
    • 15
    • 14
    • 8
    • 8
    • 7
    • 7
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 106-135
    Reaktivität
    • 92
    • 61
    • 23
    • 19
    • 15
    Human
    Wirt
    • 96
    • 19
    Kaninchen
    Klonalität
    • 94
    • 21
    Polyklonal
    Konjugat
    • 61
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser FADD Antikörper ist unkonjugiert
    Applikation
    • 84
    • 48
    • 30
    • 15
    • 15
    • 11
    • 11
    • 5
    • 5
    • 5
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This FADD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 106-135 amino acids from the Central region of human FADD.
    Klon
    RB40884
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product FADD Primärantikörper
  • Applikationshinweise
    WB: 1:1000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Haltbarkeit
    6 months
  • Papoff, Trivieri, Crielesi, Ruberti, Marsilio, Ruberti: "FADD-calmodulin interaction: a novel player in cell cycle regulation." in: Biochimica et biophysica acta, Vol. 1803, Issue 8, pp. 898-911, (2010) (PubMed).

    Li, Jayarama, Ganesh, Mordi, Carr, Kanteti, Hay, Prabhakar: "Akt-phosphorylated mitogen-activated kinase-activating death domain protein (MADD) inhibits TRAIL-induced apoptosis by blocking Fas-associated death domain (FADD) association with death receptor 4." in: The Journal of biological chemistry, Vol. 285, Issue 29, pp. 22713-22, (2010) (PubMed).

    Ko, Yang, Chung, Wen, Hsu, Miaw, Hsia: "Lack of Fas-pathway gene mutations in primary resected esophageal squamous cell carcinoma." in: Chang Gung medical journal, Vol. 33, Issue 2, pp. 145-51, (2010) (PubMed).

    Hindryckx, De Vos, Jacques, Ferdinande, Peeters, Olievier, Bogaert, Brinkman, Vandenabeele, Elewaut, Laukens: "Hydroxylase inhibition abrogates TNF-alpha-induced intestinal epithelial damage by hypoxia-inducible factor-1-dependent repression of FADD." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 10, pp. 6306-16, (2010) (PubMed).

    Silva, Blanton, Parrado, Melo, Morato, Reis, Dias, Castro, Vasconcelos, Goddard, Barreto, Reis, Teixeira: "Dengue hemorrhagic fever is associated with polymorphisms in JAK1." in: European journal of human genetics : EJHG, Vol. 18, Issue 11, pp. 1221-7, (2010) (PubMed).

  • Target
    FADD (Fas (TNFRSF6)-Associated Via Death Domain (FADD))
    Andere Bezeichnung
    FADD (FADD Produkte)
    Synonyme
    MORT1 antikoerper, Mort1/FADD antikoerper, Mort1 antikoerper, TNFRSF6 antikoerper, adaptor antikoerper, fadd antikoerper, mort1 antikoerper, xfadd antikoerper, Fas associated via death domain antikoerper, Fas (TNFRSF6)-associated via death domain antikoerper, Fas associated via death domain S homeolog antikoerper, Fas (tnfrsf6)-associated via death domain antikoerper, FADD antikoerper, Fadd antikoerper, fadd.S antikoerper, fadd antikoerper
    Hintergrund
    The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.
    Molekulargewicht
    23279
    NCBI Accession
    NP_003815
    UniProt
    Q13158
    Pathways
    Apoptose, TLR Signalweg, Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades
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