Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Aufreinigung
This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This Mouse Fap antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 15-41 amino acids from the N-terminal region of mouse Fap.
FAP
Reaktivität: Human
ELISA, IHC
Wirt: Kaninchen
Polyclonal
unconjugated
Applikationshinweise
WB: 1:2000. WB: 1:500. IHC-P: 1:100
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Buffer
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C,-20 °C
Haltbarkeit
6 months
Wen, Wang, Ma, Li, Zhou, Mu, Leng, Shi, Li, Wei: "Immunotherapy targeting fibroblast activation protein inhibits tumor growth and increases survival in a murine colon cancer model." in: Cancer science, Vol. 101, Issue 11, pp. 2325-32, (2010) (PubMed).
Santos, Jung, Aziz, Kissil, Puré: "Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in mice." in: The Journal of clinical investigation, Vol. 119, Issue 12, pp. 3613-25, (2009) (PubMed).
Kennedy, Dong, Chen, Chen: "Elevation of seprase expression and promotion of an invasive phenotype by collagenous matrices in ovarian tumor cells." in: International journal of cancer. Journal international du cancer, Vol. 124, Issue 1, pp. 27-35, (2008) (PubMed).
In association with DPP4 is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM (By similarity). May have a role in tissue remodeling during development and wound healing, and contribute to invasiveness in malignant cancers.