Frataxin Antikörper (N-Term)

Produktnummer ABIN1881356

Produktdetails anti-Frataxin Antikörper

Target: Frataxin (FXN)

Bindungsspezifität: AA 36-64, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Frataxin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This FXN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 36-64 amino acids from the N-terminal region of human FXN.

Klon: RB41914

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-Frataxin Antikörper (ABIN1881356)

Tsai, Barondeau: "Human frataxin is an allosteric switch that activates the Fe-S cluster biosynthetic complex." in: Biochemistry, Vol. 49, Issue 43, pp. 9132-9, (2010) (PubMed).

Thierbach, Drewes, Fusser, Voigt, Kuhlow, Blume, Schulz, Reiche, Glatt, Epe, Steinberg, Ristow: "The Friedreich's ataxia protein frataxin modulates DNA base excision repair in prokaryotes and mammals." in: The Biochemical journal, Vol. 432, Issue 1, pp. 165-72, (2010) (PubMed).

Mariño, Zaldivar, Mesa, Mederos, Rodríguez, Gotay, Labrada, Ochoa, Macleod, Pérez: "Low predisposition to instability of the Friedreich ataxia gene in Cuban population." in: Clinical genetics, Vol. 77, Issue 6, pp. 598-600, (2010) (PubMed).

Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, (2010) (PubMed).

Details zu Frataxin

Target: Frataxin (FXN)

Andere Bezeichnung: FXN (FXN Produkte)

Synonyme: zgc:158218 antikoerper, LOC100284365 antikoerper, BcDNA:AT09528 antikoerper, CG8971 antikoerper, DFH antikoerper, Dfh antikoerper, Dmel\\CG8971 antikoerper, X25 antikoerper, dfh antikoerper, CyaY antikoerper, FA antikoerper, FARR antikoerper, FRDA antikoerper, RGD1565754 antikoerper, Frda antikoerper, frataxin antikoerper, fxn antikoerper, LOC100284365 antikoerper, TVAG_182150 antikoerper, fh antikoerper, FTX1 antikoerper, FXN antikoerper, Fxn antikoerper

Hintergrund: This nuclear gene encodes a mitochondrial protein which belongs to FRATAXIN family. The protein functions in regulating mitochondrial iron transport and respiration. The expansion of intronic trinucleotide repeat GAA results in Friedreich ataxia. Alternative splicing results in multiple transcript variants.

Molekulargewicht: 23135

NCBI Accession: NP_000135, NP_001155178, NP_852090

UniProt: Q16595

Pathways: Transition Metal Ion Homeostasis, Regulation of Cell Size